Abstract
Further chemical investigation of a marine-derived bacterium of the genus Streptomyces has led to the isolation of ansalactams B-D (1-3) along with the previously reported metabolite ansalactam A (4). Ansalactams B-D are significantly modified ansamycins, representing three new carbon skeletons and further illustrating the biosynthetic plasticity of the ansalactam class. Unlike ansalactam A, ansalactams B and D are penta- and hexacyclic metabolites, while ansalactam C illustrates an open polyene chain with a terminal carboxylic acid.
Original language | English |
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Pages (from-to) | 2256-2259 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 18 |
Issue number | 9 |
DOIs | |
State | Published - 6 May 2016 |
Bibliographical note
Funding Information:The present study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT and Future Planning (NRF- 2014R1A1A1003492 and NRF- 2016R1A2A1A05005078), and by the U.S. National Cancer Institute (NIH) under Grant No. R37CA044848 and Instrument Grant No. 1 S10 OD0106400-01A1 (HR?LC?MS, both to W.F.).
Publisher Copyright:
© 2016 American Chemical Society.