@article{c2febf06405a41ea9ea863f5f0ad06af,
title = "Ansalactams B-D Illustrate Further Biosynthetic Plasticity within the Ansamycin Pathway",
abstract = "Further chemical investigation of a marine-derived bacterium of the genus Streptomyces has led to the isolation of ansalactams B-D (1-3) along with the previously reported metabolite ansalactam A (4). Ansalactams B-D are significantly modified ansamycins, representing three new carbon skeletons and further illustrating the biosynthetic plasticity of the ansalactam class. Unlike ansalactam A, ansalactams B and D are penta- and hexacyclic metabolites, while ansalactam C illustrates an open polyene chain with a terminal carboxylic acid.",
author = "Le, {Tu Cam} and Inho Yang and Yoon, {Yeo Joon} and Nam, {Sang Jip} and William Fenical",
note = "Funding Information: The present study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT and Future Planning (NRF- 2014R1A1A1003492 and NRF- 2016R1A2A1A05005078), and by the U.S. National Cancer Institute (NIH) under Grant No. R37CA044848 and Instrument Grant No. 1 S10 OD0106400-01A1 (HR?LC?MS, both to W.F.). Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",
year = "2016",
month = may,
day = "6",
doi = "10.1021/acs.orglett.6b00892",
language = "English",
volume = "18",
pages = "2256--2259",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "9",
}