Ansalactams B-D Illustrate Further Biosynthetic Plasticity within the Ansamycin Pathway

Tu Cam Le, Inho Yang, Yeo Joon Yoon, Sang Jip Nam, William Fenical

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Further chemical investigation of a marine-derived bacterium of the genus Streptomyces has led to the isolation of ansalactams B-D (1-3) along with the previously reported metabolite ansalactam A (4). Ansalactams B-D are significantly modified ansamycins, representing three new carbon skeletons and further illustrating the biosynthetic plasticity of the ansalactam class. Unlike ansalactam A, ansalactams B and D are penta- and hexacyclic metabolites, while ansalactam C illustrates an open polyene chain with a terminal carboxylic acid.

Original languageEnglish
Pages (from-to)2256-2259
Number of pages4
JournalOrganic Letters
Volume18
Issue number9
DOIs
StatePublished - 6 May 2016

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