Annual average changes in adult obesity as a risk factor for papillary thyroid cancer: A large-scale case-control study

Yunji Hwang, Kyu Eun Lee, Young Joo Park, Su Jin Kim, Hyungju Kwon, Do Joon Park, Belong Cho, Ho Chun Choi, Daehee Kang, Sue K. Park

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22 Scopus citations

Abstract

We evaluated the association between weight change in middle-aged adults and papillary thyroid cancer (PTC) based on a largescale case-control study. Our study included data from 1551 PTC patients (19.3% men and 80.7% women) who underwent thyroidectomy at the 3 general hospitals in Korea and 15,510 individually matched control subjects. The subjects' weight history, epidemiologic information, and tumor characteristics confirmed after thyroidectomy were analyzed. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were determined for the annual average changes in weight and obesity indicators (body mass index (BMI), body surface area, and body fat percentage (BF%) in subjects since the age of 35 years. Subjects with a total weight gain-10 kg after age 35 years were more likely to havePTC(men,OR, 5.39, 95%CI, 3.88-7.49; women,OR, 3.36, 95% CI, 2.87-3.93) compared with subjects with a stable weight (loss or gain<5 kg).Amarked increase inBMI since age 35 years (annual average change of BMI -0.3 kg/m2/yr) was related to an elevated PTC risk, and the association was more pronounced for large-sized PTC risks (<1cm, OR, 2.34, 95% CI, 1.92-2.85; -1 cm, OR, 4.00, 95% CI, 2.91-5.49, P heterogeneity=0.005) compared with low PTC risks. Weight gain and annual increases in obesity indicators in middleaged adults may increase the risk of developing PTC.

Original languageEnglish
Article numbere2893
JournalMedicine (United States)
Volume95
Issue number9
DOIs
StatePublished - 4 Mar 2016

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