Anmindenols A and B, inducible nitric oxide synthase inhibitors from a marine-derived Streptomyces sp.

Jihye Lee; Hiyoung Kim; Tae Gu Lee; Inho Yang; Dong Hwan Won; Hyukjae Choi; Sang Jip Nam; Heonjoong Kang

doi:10.1021/np500285a

Anmindenols A and B, inducible nitric oxide synthase inhibitors from a marine-derived Streptomyces sp.

Jihye Lee, Hiyoung Kim, Tae Gu Lee, Inho Yang, Dong Hwan Won, Hyukjae Choi, Sang Jip Nam, Heonjoong Kang

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Anmindenols A (1) and B (2), inhibitors of inducible nitric oxide synthase (iNOS), were isolated from a marine-derived bacterium Streptomyces sp. Their chemical structures were elucidated by interpreting various spectroscopic data, including IR, MS, and NMR. Anmindenols A and B are sesquiterpenoids possessing an indene moiety with five- and six-membered rings derived from isoprenyl units. The absolute configuration of C-4 in anmindenol B was determined by electronic circular dichroism (ECD) of a dimolybdenum complex. Anmindenols A (1) and B (2) inhibited nitric oxide production in stimulated RAW 264.7 macrophage cells with IC₅₀ values of 23 and 19 μM, respectively.

Original language	English
Pages (from-to)	1528-1531
Number of pages	4
Journal	Journal of Natural Products
Volume	77
Issue number	6
DOIs	https://doi.org/10.1021/np500285a
State	Published - 27 Jun 2014

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abstract = "Anmindenols A (1) and B (2), inhibitors of inducible nitric oxide synthase (iNOS), were isolated from a marine-derived bacterium Streptomyces sp. Their chemical structures were elucidated by interpreting various spectroscopic data, including IR, MS, and NMR. Anmindenols A and B are sesquiterpenoids possessing an indene moiety with five- and six-membered rings derived from isoprenyl units. The absolute configuration of C-4 in anmindenol B was determined by electronic circular dichroism (ECD) of a dimolybdenum complex. Anmindenols A (1) and B (2) inhibited nitric oxide production in stimulated RAW 264.7 macrophage cells with IC50 values of 23 and 19 μM, respectively.",

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AU - Lee, Jihye

AU - Kim, Hiyoung

AU - Lee, Tae Gu

AU - Yang, Inho

AU - Won, Dong Hwan

AU - Choi, Hyukjae

AU - Nam, Sang Jip

AU - Kang, Heonjoong

PY - 2014/6/27

Y1 - 2014/6/27

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AB - Anmindenols A (1) and B (2), inhibitors of inducible nitric oxide synthase (iNOS), were isolated from a marine-derived bacterium Streptomyces sp. Their chemical structures were elucidated by interpreting various spectroscopic data, including IR, MS, and NMR. Anmindenols A and B are sesquiterpenoids possessing an indene moiety with five- and six-membered rings derived from isoprenyl units. The absolute configuration of C-4 in anmindenol B was determined by electronic circular dichroism (ECD) of a dimolybdenum complex. Anmindenols A (1) and B (2) inhibited nitric oxide production in stimulated RAW 264.7 macrophage cells with IC50 values of 23 and 19 μM, respectively.

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Anmindenols A and B, inducible nitric oxide synthase inhibitors from a marine-derived Streptomyces sp.

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