Anmindenols A and B, inducible nitric oxide synthase inhibitors from a marine-derived Streptomyces sp.

Jihye Lee, Hiyoung Kim, Tae Gu Lee, Inho Yang, Dong Hwan Won, Hyukjae Choi, Sang Jip Nam, Heonjoong Kang

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23 Scopus citations

Abstract

Anmindenols A (1) and B (2), inhibitors of inducible nitric oxide synthase (iNOS), were isolated from a marine-derived bacterium Streptomyces sp. Their chemical structures were elucidated by interpreting various spectroscopic data, including IR, MS, and NMR. Anmindenols A and B are sesquiterpenoids possessing an indene moiety with five- and six-membered rings derived from isoprenyl units. The absolute configuration of C-4 in anmindenol B was determined by electronic circular dichroism (ECD) of a dimolybdenum complex. Anmindenols A (1) and B (2) inhibited nitric oxide production in stimulated RAW 264.7 macrophage cells with IC50 values of 23 and 19 μM, respectively.

Original languageEnglish
Pages (from-to)1528-1531
Number of pages4
JournalJournal of Natural Products
Volume77
Issue number6
DOIs
StatePublished - 27 Jun 2014

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