Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived streptomyces sp.

Hiyoung Kim, Inho Yang, Rahul S. Patil, Sinwoo Kang, Jihye Lee, Hyukjae Choi, Min Sun Kim, Sang Jip Nam, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Intensive investigation of the chemical components of a Streptomyces sp. isolated from mudflat sediments collected on the southern coast of the Korean peninsula led to the isolation of three new compounds, anithiactins A-C (1-3). The chemical structures of anithiactins A and C were determined by interpretation of NMR data analyses, while the chemical structure of anithiactin B was established from a combination of NMR spectroscopic and crystallographic data analyses. The structure of anithiactin A was also confirmed by total synthesis. These three anithiactins displayed moderate acetylcholinesterase inhibitory activity with no significant cytotoxicity.

Original languageEnglish
Pages (from-to)2716-2719
Number of pages4
JournalJournal of Natural Products
Issue number12
StatePublished - 26 Dec 2014

Bibliographical note

Publisher Copyright:
© 2014 The American Chemical Society and American Society of Pharmacognosy.


Dive into the research topics of 'Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived streptomyces sp.'. Together they form a unique fingerprint.

Cite this