Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived streptomyces sp.

Hiyoung Kim, Inho Yang, Rahul S. Patil, Sinwoo Kang, Jihye Lee, Hyukjae Choi, Min Sun Kim, Sang Jip Nam, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Intensive investigation of the chemical components of a Streptomyces sp. isolated from mudflat sediments collected on the southern coast of the Korean peninsula led to the isolation of three new compounds, anithiactins A-C (1-3). The chemical structures of anithiactins A and C were determined by interpretation of NMR data analyses, while the chemical structure of anithiactin B was established from a combination of NMR spectroscopic and crystallographic data analyses. The structure of anithiactin A was also confirmed by total synthesis. These three anithiactins displayed moderate acetylcholinesterase inhibitory activity with no significant cytotoxicity.

Original languageEnglish
Pages (from-to)2716-2719
Number of pages4
JournalJournal of Natural Products
Volume77
Issue number12
DOIs
StatePublished - 26 Dec 2014

Bibliographical note

Publisher Copyright:
© 2014 The American Chemical Society and American Society of Pharmacognosy.

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