TY - JOUR
T1 - Anisotropic Plasmonic Gold Nanorod-Indocyanine Green@Reduced Graphene Oxide-Doxorubicin Nanohybrids for Image-Guided Enhanced Tumor Theranostics
AU - Maji, Swarup Kumar
AU - Yu, Subin
AU - Choi, Eunshil
AU - Lim, Ju Won
AU - Jang, Dohyub
AU - Kim, Ga Young
AU - Kim, Sehoon
AU - Lee, Hyukjin
AU - Kim, Dong Ha
N1 - Funding Information:
This work was supported by a National Research Foundation (NRF) of Korea grant funded by the Korean Government (NRF-2020R 1A 2C 3003958), by the Basic Science Research Program (Priority Research Institute) through the NRF funded by the Ministry of Education (2021R 1A 6A 1A10039823), and by a Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Ministry of Education (2020R 1A 6C 101B194). The work at Korea Institute of Science and Technology was supported by funds from the National Research Foundation of Korea (2021R1A2C2005418), and the KIST intramural program. Dr. Maji is thankful to the Department of Higher Education, Science and Technology & Biotechnology, Government of West Bengal, India, for granting special study leave from his academic position at Khatra Adibasi Mahavidyalaya, India.
Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.
PY - 2022/5/3
Y1 - 2022/5/3
N2 - The unique physicochemical and localized surface plasmon resonance assets of gold nanorods (GNRs) have offered combined cancer treatments with real-time diagnosis by integrating diverse theragnostic modalities into a single nanoplatform. In this work, a unique multifunctional nanohybrid material based on GNRs was designed for in vitro and in vivo tumor imaging along with synergistic and combinatorial therapy of tumor. The hybrid material with size less than 100 nm was achieved by embedding indocyanine green (ICG) on mesoporous silica-coated GNRs with further wrapping of reduced graphene oxide (rGO) and then attached with doxorubicin (DOX) and polyethylene glycol. The nanohybrid unveiled noteworthy stability and competently protected the embedded ICG from further aggregation, photobleaching, and nucleophilic attack by encapsulation of GNRs-ICG with rGO. Such combination of GNRs-ICG with rGO and DOX served as a real-time near-infrared (NIR) contrast imaging agent for cancer diagnosis. The hybrid material exhibits high NIR absorption property along with three destined capabilities, such as, nanozymatic activity, photothermal activity, and an excellent drug carrier for drug delivery. The integrated properties of the nanohybrid were then utilized for the triple mode of combined therapeutics of tumor cells, through synergistic catalytic therapy and chemotherapy with combinatorial photothermal therapy to achieve the maximum cancer killing efficiency. It is assumed that the assimilated multimodal imaging and therapeutic capability in single nanoparticle platform is advantageous for future practical applications in cancer diagnosis, therapy, and molecular imaging.
AB - The unique physicochemical and localized surface plasmon resonance assets of gold nanorods (GNRs) have offered combined cancer treatments with real-time diagnosis by integrating diverse theragnostic modalities into a single nanoplatform. In this work, a unique multifunctional nanohybrid material based on GNRs was designed for in vitro and in vivo tumor imaging along with synergistic and combinatorial therapy of tumor. The hybrid material with size less than 100 nm was achieved by embedding indocyanine green (ICG) on mesoporous silica-coated GNRs with further wrapping of reduced graphene oxide (rGO) and then attached with doxorubicin (DOX) and polyethylene glycol. The nanohybrid unveiled noteworthy stability and competently protected the embedded ICG from further aggregation, photobleaching, and nucleophilic attack by encapsulation of GNRs-ICG with rGO. Such combination of GNRs-ICG with rGO and DOX served as a real-time near-infrared (NIR) contrast imaging agent for cancer diagnosis. The hybrid material exhibits high NIR absorption property along with three destined capabilities, such as, nanozymatic activity, photothermal activity, and an excellent drug carrier for drug delivery. The integrated properties of the nanohybrid were then utilized for the triple mode of combined therapeutics of tumor cells, through synergistic catalytic therapy and chemotherapy with combinatorial photothermal therapy to achieve the maximum cancer killing efficiency. It is assumed that the assimilated multimodal imaging and therapeutic capability in single nanoparticle platform is advantageous for future practical applications in cancer diagnosis, therapy, and molecular imaging.
UR - http://www.scopus.com/inward/record.url?scp=85129577428&partnerID=8YFLogxK
U2 - 10.1021/acsomega.2c01306
DO - 10.1021/acsomega.2c01306
M3 - Article
AN - SCOPUS:85129577428
SN - 2470-1343
VL - 7
SP - 15186
EP - 15199
JO - ACS Omega
JF - ACS Omega
IS - 17
ER -