Angelica keiskei Impacts the Lifespan and Healthspan of Drosophila melanogaster in a Sex and Strain-Dependent Manner

Mahtab Jafari, Samuel E. Schriner, Yun Seo Kil, Sally T. Pham, Eun Kyoung Seo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Angelica keiskei is a perennial plant, belonging to the Apiaceae family and originating from Japan. This plant has been reported to act as a diuretic, analeptic, antidiabetic, hypertensive, tumor, galactagogue, and laxative. The mechanism of action of A. keiskei is not known, but previous studies have suggested that it may act as an antioxidant. In this work, we used Drosophila melanogaster to evaluate the impact of A. keiskei on lifespan and healthspan and its potential anti-aging mechanism by conducting multiple assays on three fly strains: w1118, chico, and JIV. We observed that the extract extended lifespan and improved healthspan in a sex- and strain-dependent manner. A. keiskei extended lifespan and improved reproductive fitness in female flies and either had no effect or decreased survival and physical performance in males. The extract protected against the superoxide generator paraquat in both sexes. These sex-specific effects suggest that A. keiskei may act through age-specific pathways such as the insulin and insulin-like growth factor signaling (IIS) pathways. Upon examination, we found that the increased survival of A. keiskei-fed females was dependent on the presence of the insulin receptor substrate chico, supporting the role of IIS in the action of A. keiskei.

Original languageEnglish
Article number738
JournalPharmaceuticals
Volume16
Issue number5
DOIs
StatePublished - May 2023

Bibliographical note

Funding Information:
This work received no funding from an external funding agency. The work was partially supported by a grant from the Undergraduate Research Opportunities Program (UROP) at the University of California, Irvine that provides small grants to students’ research projects.

Publisher Copyright:
© 2023 by the authors.

Keywords

  • Angelica keiskei
  • Apiaceae
  • Drosophila melanogaster
  • healthspan
  • insulin/IGF-1 pathway
  • lifespan

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