Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells

Jihye Lee; Chathurika D.B. Gamage; Geum Jin Kim; Prima F. Hillman; Chaeyoung Lee; Eun Young Lee; Hyukjae Choi; Hangun Kim; Sang Jip Nam; William Fenical

doi:10.1021/acs.jnatprod.0c00815

Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells

Jihye Lee
, Chathurika D.B. Gamage
, Geum Jin Kim
, Prima F. Hillman
, Chaeyoung Lee
, Eun Young Lee
, Hyukjae Choi
, Hangun Kim
, Sang Jip Nam
, William Fenical

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of 1 were determined by application of the Marfey's and advanced Marfey's methods. Androsamide (1) strongly suppressed the motility of Caco2 cells caused by epithelial-mesenchymal transition.

Original language	English
Pages (from-to)	3166-3172
Number of pages	7
Journal	Journal of Natural Products
Volume	83
Issue number	10
DOIs	https://doi.org/10.1021/acs.jnatprod.0c00815
State	Published - 23 Oct 2020

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title = "Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells",

abstract = "A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of 1 were determined by application of the Marfey's and advanced Marfey's methods. Androsamide (1) strongly suppressed the motility of Caco2 cells caused by epithelial-mesenchymal transition.",

author = "Jihye Lee and Gamage, \{Chathurika D.B.\} and Kim, \{Geum Jin\} and Hillman, \{Prima F.\} and Chaeyoung Lee and Lee, \{Eun Young\} and Hyukjae Choi and Hangun Kim and Nam, \{Sang Jip\} and William Fenical",

note = "Publisher Copyright: {\textcopyright} ",

year = "2020",

month = oct,

day = "23",

doi = "10.1021/acs.jnatprod.0c00815",

language = "English",

volume = "83",

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T1 - Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells

AU - Lee, Jihye

AU - Gamage, Chathurika D.B.

AU - Kim, Geum Jin

AU - Hillman, Prima F.

AU - Lee, Chaeyoung

AU - Lee, Eun Young

AU - Choi, Hyukjae

AU - Kim, Hangun

AU - Nam, Sang Jip

AU - Fenical, William

PY - 2020/10/23

Y1 - 2020/10/23

N2 - A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of 1 were determined by application of the Marfey's and advanced Marfey's methods. Androsamide (1) strongly suppressed the motility of Caco2 cells caused by epithelial-mesenchymal transition.

AB - A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of 1 were determined by application of the Marfey's and advanced Marfey's methods. Androsamide (1) strongly suppressed the motility of Caco2 cells caused by epithelial-mesenchymal transition.

UR - https://www.scopus.com/pages/publications/85094220897

U2 - 10.1021/acs.jnatprod.0c00815

DO - 10.1021/acs.jnatprod.0c00815

M3 - Article

C2 - 32985880

AN - SCOPUS:85094220897

SN - 0163-3864

VL - 83

SP - 3166

EP - 3172

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 10

ER -

Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells

Abstract

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