Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells

Jihye Lee; Chathurika D.B. Gamage; Geum Jin Kim; Prima F. Hillman; Chaeyoung Lee; Eun Young Lee; Hyukjae Choi; Hangun Kim; Sang Jip Nam; William Fenical

doi:10.1021/acs.jnatprod.0c00815

Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells

Jihye Lee, Chathurika D.B. Gamage, Geum Jin Kim, Prima F. Hillman, Chaeyoung Lee, Eun Young Lee, Hyukjae Choi, Hangun Kim, Sang Jip Nam, William Fenical

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of 1 were determined by application of the Marfey's and advanced Marfey's methods. Androsamide (1) strongly suppressed the motility of Caco2 cells caused by epithelial-mesenchymal transition.

Original language	English
Pages (from-to)	3166-3172
Number of pages	7
Journal	Journal of Natural Products
Volume	83
Issue number	10
DOIs	https://doi.org/10.1021/acs.jnatprod.0c00815
State	Published - 23 Oct 2020

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title = "Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells",

abstract = "A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of 1 were determined by application of the Marfey's and advanced Marfey's methods. Androsamide (1) strongly suppressed the motility of Caco2 cells caused by epithelial-mesenchymal transition.",

author = "Jihye Lee and Gamage, {Chathurika D.B.} and Kim, {Geum Jin} and Hillman, {Prima F.} and Chaeyoung Lee and Lee, {Eun Young} and Hyukjae Choi and Hangun Kim and Nam, {Sang Jip} and William Fenical",

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doi = "10.1021/acs.jnatprod.0c00815",

language = "English",

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T1 - Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells

AU - Lee, Jihye

AU - Gamage, Chathurika D.B.

AU - Kim, Geum Jin

AU - Hillman, Prima F.

AU - Lee, Chaeyoung

AU - Lee, Eun Young

AU - Choi, Hyukjae

AU - Kim, Hangun

AU - Nam, Sang Jip

AU - Fenical, William

PY - 2020/10/23

Y1 - 2020/10/23

N2 - A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of 1 were determined by application of the Marfey's and advanced Marfey's methods. Androsamide (1) strongly suppressed the motility of Caco2 cells caused by epithelial-mesenchymal transition.

AB - A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of 1 were determined by application of the Marfey's and advanced Marfey's methods. Androsamide (1) strongly suppressed the motility of Caco2 cells caused by epithelial-mesenchymal transition.

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U2 - 10.1021/acs.jnatprod.0c00815

DO - 10.1021/acs.jnatprod.0c00815

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SN - 0163-3864

VL - 83

SP - 3166

EP - 3172

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 10

ER -

Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells

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