Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells

Jihye Lee, Chathurika D.B. Gamage, Geum Jin Kim, Prima F. Hillman, Chaeyoung Lee, Eun Young Lee, Hyukjae Choi, Hangun Kim, Sang Jip Nam, William Fenical

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of 1 were determined by application of the Marfey's and advanced Marfey's methods. Androsamide (1) strongly suppressed the motility of Caco2 cells caused by epithelial-mesenchymal transition.

Original languageEnglish
Pages (from-to)3166-3172
Number of pages7
JournalJournal of Natural Products
Volume83
Issue number10
DOIs
StatePublished - 23 Oct 2020

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