Androgen deprivation therapy during and after post-prostatectomy radiotherapy in patients with prostate cancer: A case control study

Myong Kim, Cheryn Song, In Gab Jeong, Seung Kwon Choi, Myungchan Park, Myungsun Shim, Young Seok Kim, Dalsan You, Jun Hyuk Hong, Choung Soo Kim, Hanjong Ahn

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Here we assessed the influence of androgen deprivation therapy (ADT) during and/or after post-prostatectomy radiotherapy (RT) on biochemical recurrence (BCR) and radiographic progression in patients with prostate cancer. Methods: Patients with prostate cancer who underwent post-prostatectomy RT were analyzed. BCR and radiographic progression after RT were compared according to the concurrent or salvage ADT. Cox regression analyses were used to identify risk factors for BCR and radiographic progression. Results: Of the 227 patients who underwent post-prostatectomy RT, 95 (41.9%) received concurrent ADT for a median of 17.0 months. Despite more aggressive disease characteristics in the concurrent ADT group than in the RT-only group, the former had a better 5-year BCR-free survival rate than the latter (66.1 vs. 53.9%; p = 0.016), whereas the radiographic progression rate was not significantly different between two groups. On the other hand, salvage ADT after post-RT BCR significantly delayed radiographic progression (5-year radiographic progression-free survival; 75.2 vs. 44.5%; p = 0.002). Conclusions: Concurrent ADT improved BCR-free survival, and salvage ADT after post-RT BCR improved radiographic progression-free survival. To maximize the oncological benefit, ADT of sufficient duration should be implemented.

Original languageEnglish
Article number271
JournalBMC Cancer
Volume18
Issue number1
DOIs
StatePublished - 9 Mar 2018

Keywords

  • Androgen-deprivation therapy
  • Prognostic factor
  • Prostate cancer
  • Radiotherapy
  • Survival

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