Anatomical correlates of early mutism in progressive nonfluent aphasia

M. L. Gorno-Tempini; J. M. Ogar; S. M. Brambati; P. Wang; J. H. Jeong; K. P. Rankin; N. F. Dronkers; B. L. Miller

doi:10.1212/01.wnl.0000237038.55627.5b

Anatomical correlates of early mutism in progressive nonfluent aphasia

M. L. Gorno-Tempini, J. M. Ogar, S. M. Brambati, P. Wang, J. H. Jeong, K. P. Rankin, N. F. Dronkers, B. L. Miller

Department of Neurology

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Patients with progressive nonfluent aphasia (PNFA) can become mute early in the course of the disease. Voxel-based morphometry showed that PNFA is associated with left anterior insula and inferior frontal atrophy. In PNFA with early mutism, volume loss was more prominent in the pars opercularis and extended into the left basal ganglia. Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in PNFA.

Original language	English
Pages (from-to)	1849-1851
Number of pages	3
Journal	Neurology
Volume	67
Issue number	10
DOIs	https://doi.org/10.1212/01.wnl.0000237038.55627.5b
State	Published - Nov 2006

Bibliographical note

Funding Information:
Supported by the National Institute of Neurological Disorders and Stroke (R01 NS050915), the State of California (DHS 04-35516), the National Institute on Aging (P50 AG03006, P01 AG019724), the John Douglas French Alzheimer's Foundation, the McBean Foundation, the Sandler Foundation, the AD Research Center of California (03-75271 DHS/ADP/ARCC), the Larry Hillblom Foundation (grant 2002/2F), and the Koret Foundation (grant 99-0102).

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title = "Anatomical correlates of early mutism in progressive nonfluent aphasia",

abstract = "Patients with progressive nonfluent aphasia (PNFA) can become mute early in the course of the disease. Voxel-based morphometry showed that PNFA is associated with left anterior insula and inferior frontal atrophy. In PNFA with early mutism, volume loss was more prominent in the pars opercularis and extended into the left basal ganglia. Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in PNFA.",

author = "Gorno-Tempini, {M. L.} and Ogar, {J. M.} and Brambati, {S. M.} and P. Wang and Jeong, {J. H.} and Rankin, {K. P.} and Dronkers, {N. F.} and Miller, {B. L.}",

note = "Funding Information: Supported by the National Institute of Neurological Disorders and Stroke (R01 NS050915), the State of California (DHS 04-35516), the National Institute on Aging (P50 AG03006, P01 AG019724), the John Douglas French Alzheimer's Foundation, the McBean Foundation, the Sandler Foundation, the AD Research Center of California (03-75271 DHS/ADP/ARCC), the Larry Hillblom Foundation (grant 2002/2F), and the Koret Foundation (grant 99-0102). ",

year = "2006",

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doi = "10.1212/01.wnl.0000237038.55627.5b",

language = "English",

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AU - Gorno-Tempini, M. L.

AU - Ogar, J. M.

AU - Brambati, S. M.

AU - Wang, P.

AU - Jeong, J. H.

AU - Rankin, K. P.

AU - Dronkers, N. F.

AU - Miller, B. L.

N1 - Funding Information: Supported by the National Institute of Neurological Disorders and Stroke (R01 NS050915), the State of California (DHS 04-35516), the National Institute on Aging (P50 AG03006, P01 AG019724), the John Douglas French Alzheimer's Foundation, the McBean Foundation, the Sandler Foundation, the AD Research Center of California (03-75271 DHS/ADP/ARCC), the Larry Hillblom Foundation (grant 2002/2F), and the Koret Foundation (grant 99-0102).

PY - 2006/11

Y1 - 2006/11

N2 - Patients with progressive nonfluent aphasia (PNFA) can become mute early in the course of the disease. Voxel-based morphometry showed that PNFA is associated with left anterior insula and inferior frontal atrophy. In PNFA with early mutism, volume loss was more prominent in the pars opercularis and extended into the left basal ganglia. Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in PNFA.

AB - Patients with progressive nonfluent aphasia (PNFA) can become mute early in the course of the disease. Voxel-based morphometry showed that PNFA is associated with left anterior insula and inferior frontal atrophy. In PNFA with early mutism, volume loss was more prominent in the pars opercularis and extended into the left basal ganglia. Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in PNFA.

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Anatomical correlates of early mutism in progressive nonfluent aphasia

Abstract

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