Anatomical correlates of early mutism in progressive nonfluent aphasia

M. L. Gorno-Tempini, J. M. Ogar, S. M. Brambati, P. Wang, J. H. Jeong, K. P. Rankin, N. F. Dronkers, B. L. Miller

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Patients with progressive nonfluent aphasia (PNFA) can become mute early in the course of the disease. Voxel-based morphometry showed that PNFA is associated with left anterior insula and inferior frontal atrophy. In PNFA with early mutism, volume loss was more prominent in the pars opercularis and extended into the left basal ganglia. Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in PNFA.

Original languageEnglish
Pages (from-to)1849-1851
Number of pages3
Issue number10
StatePublished - Nov 2006

Bibliographical note

Funding Information:
Supported by the National Institute of Neurological Disorders and Stroke (R01 NS050915), the State of California (DHS 04-35516), the National Institute on Aging (P50 AG03006, P01 AG019724), the John Douglas French Alzheimer's Foundation, the McBean Foundation, the Sandler Foundation, the AD Research Center of California (03-75271 DHS/ADP/ARCC), the Larry Hillblom Foundation (grant 2002/2F), and the Koret Foundation (grant 99-0102).


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