Anatomical correlates of early mutism in progressive nonfluent aphasia

M. L. Gorno-Tempini, J. M. Ogar, S. M. Brambati, P. Wang, J. H. Jeong, K. P. Rankin, N. F. Dronkers, B. L. Miller

Research output: Contribution to journalArticlepeer-review


Patients with progressive nonfluent aphasia (PNFA) can become mute early in the course of the disease. Voxel-based morphometry showed that PNFA is associated with left anterior insula and inferior frontal atrophy. In PNFA with early mutism, volume loss was more prominent in the pars opercularis and extended into the left basal ganglia. Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in PNFA.

Original languageEnglish
Pages (from-to)1849-1851
Number of pages3
Issue number10
StatePublished - Nov 2006


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