Analysis of whole blood platelet translocation on a vWF-coated microfluidic flow chamber

B. Lincoln; G. Meade; N. Kent; L. Basabe-Desmonts; D. Kenny; A. J. Ricco; L. P. Lee

Analysis of whole blood platelet translocation on a vWF-coated microfluidic flow chamber

B. Lincoln, G. Meade, N. Kent, L. Basabe-Desmonts, D. Kenny, A. J. Ricco, L. P. Lee

Department of Chemistry & Nanoscience

Research output: Contribution to conference › Paper › peer-review

1 Scopus citations

Abstract

We demonstrate that by tacking and analyzing platelet translocation along a surface of vWF, which is dominated by an initial GPIbα-vWF-A1 interaction, we can detect the effects of ReoPro (abciximab) on the target receptor. These experiments were performed using whole blood, illustrating a potential for clinical application.

Original language	English
Pages	453-455
Number of pages	3
State	Published - 2008
Event	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States Duration: 12 Oct 2008 → 16 Oct 2008

Conference

Conference	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
Country/Territory	United States
City	San Diego, CA
Period	12/10/08 → 16/10/08

Keywords

Abciximab
Blood
Platelet
Von willebrand factor

Cite this

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title = "Analysis of whole blood platelet translocation on a vWF-coated microfluidic flow chamber",

abstract = "We demonstrate that by tacking and analyzing platelet translocation along a surface of vWF, which is dominated by an initial GPIbα-vWF-A1 interaction, we can detect the effects of ReoPro (abciximab) on the target receptor. These experiments were performed using whole blood, illustrating a potential for clinical application.",

keywords = "Abciximab, Blood, Platelet, Von willebrand factor",

author = "B. Lincoln and G. Meade and N. Kent and L. Basabe-Desmonts and D. Kenny and Ricco, {A. J.} and Lee, {L. P.}",

year = "2008",

language = "English",

pages = "453--455",

note = "12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 ; Conference date: 12-10-2008 Through 16-10-2008",

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TY - CONF

T1 - Analysis of whole blood platelet translocation on a vWF-coated microfluidic flow chamber

AU - Lincoln, B.

AU - Meade, G.

AU - Kent, N.

AU - Basabe-Desmonts, L.

AU - Kenny, D.

AU - Ricco, A. J.

AU - Lee, L. P.

PY - 2008

Y1 - 2008

N2 - We demonstrate that by tacking and analyzing platelet translocation along a surface of vWF, which is dominated by an initial GPIbα-vWF-A1 interaction, we can detect the effects of ReoPro (abciximab) on the target receptor. These experiments were performed using whole blood, illustrating a potential for clinical application.

AB - We demonstrate that by tacking and analyzing platelet translocation along a surface of vWF, which is dominated by an initial GPIbα-vWF-A1 interaction, we can detect the effects of ReoPro (abciximab) on the target receptor. These experiments were performed using whole blood, illustrating a potential for clinical application.

KW - Abciximab

KW - Blood

KW - Platelet

KW - Von willebrand factor

UR - http://www.scopus.com/inward/record.url?scp=84902440594&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:84902440594

SP - 453

EP - 455

T2 - 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008

Y2 - 12 October 2008 through 16 October 2008

ER -

Analysis of whole blood platelet translocation on a vWF-coated microfluidic flow chamber

Abstract

Conference

Keywords

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Cite this