Analysis of plasma metabolic profiling and evaluation of the effect of the intake of Angelica keiskei using metabolomics and lipidomics

Hyun A. Oh, Hyunbeom Lee, Soo yeon Park, Yeni Lim, Oran Kwon, Ji Yeon Kim, Donghak Kim, Byung Hwa Jung

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Ethnopharmacological relevance: Angelica keiskei contains many bioactive components with anti-oxidative and anti-inflammatory effects. It is also effective for the treatment of diabetes mellitus, hypertension, and arteriosclerosis, but the relationships between these effects and the active components in the herb have not been studied. Aim of the study: We aimed to confirm the effects of Angelica keiskei on humans. Materials and methods: A metabolomics and lipidomics study was performed using human plasma samples from 20 subjects after the intake of Angelica keiskei, and the components of Angelica keiskei in the plasma were profiled. UPLC-Orbitrap-MS was used to analyze the plasma and plant extracts, and multivariate analysis and correlation studies between the exogenous components from plant and endogenous metabolite in plasma were performed. Results: The levels of the 14 metabolites including kynurenic acid, prostaglandin E1, chenodeoxycholic acid, lysoPC (18:1), lysoPC (18:2), lysoPC (20:3), lysoPC (20:4), lysoPC (22:6), PC (34:1), PC (34:2), PC (38:3), PC (38:4), PC (38:6) and PC (40:7) in the plasma were changed. By monitoring the components originating from Angelica keiskei in plasma, five components including 5-methoxypsoralen, 8-methoxypsoralen, 4-hydroxyderricin, xanthoangelol B and xanthoangelol F were detected and they reduced the levels of bile acids and fatty acids. Conclusions: The levels of the metabolites, including bile acids, amino acids, glycerophospholipids and fatty acids, in the plasma were changed, and 14 significantly changed metabolites were closely related to the preventive effect against liver diseases, type 2 diabetes, anemia, obesity, atherosclerosis, depression and anti-inflammatory effects. The five components of Angelica keiskei were related the modulatory activity of reducing the levels of bile acids and fatty acids.

Original languageEnglish
Article number112058
JournalJournal of Ethnopharmacology
StatePublished - 28 Oct 2019

Bibliographical note

Funding Information:
This study was supported by the Creative Fusion Research Program through the Creative Allied Project funded by the Bio-Synergy Research Project ( NRF-2013M3A9C4078145 and NRF-2012M3A9C4048761 ) of the Ministry of Science, ICT and Future Planning through the National Research Foundation and by the KIST Institutional Program (Project no. 2E29290 ).

Publisher Copyright:
© 2019 Elsevier B.V.


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