Analysis of microarray right-censored data through fused sliced inverse regression

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Sufficient dimension reduction (SDR) for a regression pursue a replacement of the original p-dimensional predictors with its lower-dimensional linear projection. The so-called sliced inverse regression (SIR; [5]) arguably has the longest history in SDR methodologies, but it is still one of the most popular one. The SIR is known to be easily affected by the number of slices, which is one of its critical deficits. Recently, a fused approach for SIR is proposed to relieve this weakness, which fuses the kernel matrices computed by the SIR application from various numbers of slices. In the paper, the fused SIR is applied to a large-p-small n regression of a high-dimensional microarray right-censored data to show its practical advantage over usual SIR application. Through model validation, it is confirmed that the fused SIR outperforms the SIR with any number of slices under consideration.

Original languageEnglish
Article number15094
JournalScientific Reports
Issue number1
StatePublished - 1 Dec 2019

Bibliographical note

Funding Information:
This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Korean Ministry of Education (NRF-NRF-2019R1F1A1050715/2019R1A6A1A11051177).

Publisher Copyright:
© 2019, The Author(s).


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