TY - JOUR
T1 - An overview of recent advancements in microbial polyhydroxyalkanoates (Pha) production from dark fermentation acidogenic effluents
T2 - A path to an integrated bio-refinery
AU - Saratale, Rijuta Ganesh
AU - Cho, Si Kyung
AU - Saratale, Ganesh Dattatraya
AU - Kumar, Manu
AU - Bharagava, Ram Naresh
AU - Varjani, Sunita
AU - Kadam, Avinash A.
AU - Ghodake, Gajanan S.
AU - Palem, Ramasubba Reddy
AU - Mulla, Sikandar I.
AU - Kim, Dong Su
AU - Shin, Han Seung
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Global energy consumption has been increasing in tandem with economic growth motivating researchers to focus on renewable energy sources. Dark fermentative hydrogen synthesis utilizing various biomass resources is a promising, less costly, and less energy-intensive bioprocess relative to other biohydrogen production routes. The generated acidogenic dark fermentative effluent [e.g., volatile fatty acids (VFAs)] has potential as a reliable and sustainable carbon substrate for polyhydroxyalkanoate (PHA) synthesis. PHA, an important alternative to petrochemical based polymers has attracted interest recently, owing to its biodegradability and biocompatibility. This review illustrates methods for the conversion of acidogenic effluents (VFAs), such as acetate, butyrate, propionate, lactate, valerate, and mixtures of VFAs, into the value-added compound PHA. In addition, the review provides a comprehensive update on research progress of VFAs to PHA conversion and related enhancement techniques including optimization of operational parameters, fermentation strategies, and genetic engineering approaches. Finally, potential bottlenecks and future directions for the conversion of VFAs to PHA are outlined. This review offers insights to researchers on an integrated biorefinery route for sustainable and cost-effective bioplastics production.
AB - Global energy consumption has been increasing in tandem with economic growth motivating researchers to focus on renewable energy sources. Dark fermentative hydrogen synthesis utilizing various biomass resources is a promising, less costly, and less energy-intensive bioprocess relative to other biohydrogen production routes. The generated acidogenic dark fermentative effluent [e.g., volatile fatty acids (VFAs)] has potential as a reliable and sustainable carbon substrate for polyhydroxyalkanoate (PHA) synthesis. PHA, an important alternative to petrochemical based polymers has attracted interest recently, owing to its biodegradability and biocompatibility. This review illustrates methods for the conversion of acidogenic effluents (VFAs), such as acetate, butyrate, propionate, lactate, valerate, and mixtures of VFAs, into the value-added compound PHA. In addition, the review provides a comprehensive update on research progress of VFAs to PHA conversion and related enhancement techniques including optimization of operational parameters, fermentation strategies, and genetic engineering approaches. Finally, potential bottlenecks and future directions for the conversion of VFAs to PHA are outlined. This review offers insights to researchers on an integrated biorefinery route for sustainable and cost-effective bioplastics production.
KW - Biobased production
KW - Dark fermentative hydrogen production
KW - Genetic engineering
KW - Polyhydroxyalkanoates (PHA)
KW - Volatile fatty acids (VFAs)
UR - http://www.scopus.com/inward/record.url?scp=85121308284&partnerID=8YFLogxK
U2 - 10.3390/polym13244297
DO - 10.3390/polym13244297
M3 - Review article
AN - SCOPUS:85121308284
SN - 2073-4360
VL - 13
JO - Polymers
JF - Polymers
IS - 24
M1 - 4297
ER -