An NBD-based colorimetric and fluorescent chemosensor for Zn2+ and its use for detection of intracellular zinc ions

Zhaochao Xu; Gun Hee Kim; Su Jung Han; Min Jung Jou; Chongmok Lee; Injae Shin; Juyoung Yoon

doi:10.1016/j.tet.2009.01.035

An NBD-based colorimetric and fluorescent chemosensor for Zn²⁺ and its use for detection of intracellular zinc ions

Zhaochao Xu, Gun Hee Kim, Su Jung Han, Min Jung Jou, Chongmok Lee, Injae Shin, Juyoung Yoon

Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

A new 7-nitrobenz-2-oxa-1,3-diazole (NBD) based colorimetric and fluorescence chemosensor for Zn²⁺, an ion involved in many biological processes, was designed and synthesized. The NBD-probe 1 displays a red-to-yellow color change and an enhancement of fluorescent intensity in the presence of an aqueous solution of Zn²⁺ ions (pH 7.2). Internal charge transfer (ICT) and photoinduced electron transfer (PET) mechanisms are responsible for these changes. The practical use of this probe was demonstrated by its application to the biologically relevant detection of Zn²⁺ ions in pancreatic β-cells.

Original language	English
Pages (from-to)	2307-2312
Number of pages	6
Journal	Tetrahedron
Volume	65
Issue number	11
DOIs	https://doi.org/10.1016/j.tet.2009.01.035
State	Published - 14 Mar 2009

Bibliographical note

Funding Information:
This work was supported by grants from the NRL program (R04-2007-000-2007-0 and R0A-2005-000-10027-0), the SRC program of KOSEF/MEST (R11-2005-008 and R11-2000-070), and WCU (R31-2008-000-10010-0) program. G.-H.K and M.J.C. also thank the BK21 program (KRF). Mass spectral data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer.

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10.1016/j.tet.2009.01.035

Cite this

@article{b6d4517246394435a8e0bc33b47e9c66,

title = "An NBD-based colorimetric and fluorescent chemosensor for Zn2+ and its use for detection of intracellular zinc ions",

abstract = "A new 7-nitrobenz-2-oxa-1,3-diazole (NBD) based colorimetric and fluorescence chemosensor for Zn2+, an ion involved in many biological processes, was designed and synthesized. The NBD-probe 1 displays a red-to-yellow color change and an enhancement of fluorescent intensity in the presence of an aqueous solution of Zn2+ ions (pH 7.2). Internal charge transfer (ICT) and photoinduced electron transfer (PET) mechanisms are responsible for these changes. The practical use of this probe was demonstrated by its application to the biologically relevant detection of Zn2+ ions in pancreatic β-cells.",

author = "Zhaochao Xu and Kim, {Gun Hee} and Han, {Su Jung} and Jou, {Min Jung} and Chongmok Lee and Injae Shin and Juyoung Yoon",

note = "Funding Information: This work was supported by grants from the NRL program (R04-2007-000-2007-0 and R0A-2005-000-10027-0), the SRC program of KOSEF/MEST (R11-2005-008 and R11-2000-070), and WCU (R31-2008-000-10010-0) program. G.-H.K and M.J.C. also thank the BK21 program (KRF). Mass spectral data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer. ",

year = "2009",

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doi = "10.1016/j.tet.2009.01.035",

language = "English",

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T1 - An NBD-based colorimetric and fluorescent chemosensor for Zn2+ and its use for detection of intracellular zinc ions

AU - Xu, Zhaochao

AU - Kim, Gun Hee

AU - Han, Su Jung

AU - Jou, Min Jung

AU - Lee, Chongmok

AU - Shin, Injae

AU - Yoon, Juyoung

N1 - Funding Information: This work was supported by grants from the NRL program (R04-2007-000-2007-0 and R0A-2005-000-10027-0), the SRC program of KOSEF/MEST (R11-2005-008 and R11-2000-070), and WCU (R31-2008-000-10010-0) program. G.-H.K and M.J.C. also thank the BK21 program (KRF). Mass spectral data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer.

PY - 2009/3/14

Y1 - 2009/3/14

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AB - A new 7-nitrobenz-2-oxa-1,3-diazole (NBD) based colorimetric and fluorescence chemosensor for Zn2+, an ion involved in many biological processes, was designed and synthesized. The NBD-probe 1 displays a red-to-yellow color change and an enhancement of fluorescent intensity in the presence of an aqueous solution of Zn2+ ions (pH 7.2). Internal charge transfer (ICT) and photoinduced electron transfer (PET) mechanisms are responsible for these changes. The practical use of this probe was demonstrated by its application to the biologically relevant detection of Zn2+ ions in pancreatic β-cells.

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