An efficient two-photon fluorescent probe for human NAD(P)H:quinone oxidoreductase (hNQO1) detection and imaging in tumor cells

Nahyun Kwon, Myoung Ki Cho, Sang Jun Park, Dayoung Kim, Sang Jip Nam, Lei Cui, Hwan Myung Kim, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

A new quinone propionic acid locked TP fluorophore which can be used for human NAD(P)H:quinone oxidoreductase (hNQO1) detection was developed. The probe, TPQ, which displays high selectivity and anti-interference ability, was successfully applied to endogenous hNQO1 imaging and for the identification of different cancer cells.

Original languageEnglish
Pages (from-to)525-528
Number of pages4
JournalChemical Communications
Volume53
Issue number3
DOIs
StatePublished - 2017

Bibliographical note

Funding Information:
J. Y. acknowledges a grant from the National Creative Research Initiative Program of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (Grant 2012R1A3A2048814). H. M. K. acknowledges a grant from the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (Grant 2016R1E1A1A02920873). S. N. acknowledges the National Research Council of Science and Technology through the Degree & Research Center Program (Grant DRC-14-1-KBSI). Mass spectral data were obtained at the Korean Basic Science Institute using a Jeol JMS 700 high-resolution mass spectrometer.

Publisher Copyright:
© The Royal Society of Chemistry.

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