An efficient two-photon fluorescent probe for human NAD(P)H:quinone oxidoreductase (hNQO1) detection and imaging in tumor cells

Nahyun Kwon; Myoung Ki Cho; Sang Jun Park; Dayoung Kim; Sang Jip Nam; Lei Cui; Hwan Myung Kim; Juyoung Yoon

doi:10.1039/C6CC08971B

An efficient two-photon fluorescent probe for human NAD(P)H:quinone oxidoreductase (hNQO1) detection and imaging in tumor cells

Nahyun Kwon, Myoung Ki Cho, Sang Jun Park, Dayoung Kim, Sang Jip Nam, Lei Cui, Hwan Myung Kim, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

A new quinone propionic acid locked TP fluorophore which can be used for human NAD(P)H:quinone oxidoreductase (hNQO1) detection was developed. The probe, TPQ, which displays high selectivity and anti-interference ability, was successfully applied to endogenous hNQO1 imaging and for the identification of different cancer cells.

Original language	English
Pages (from-to)	525-528
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	3
DOIs	https://doi.org/10.1039/C6CC08971B
State	Published - 2017

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Publisher Copyright:
© The Royal Society of Chemistry.

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abstract = "A new quinone propionic acid locked TP fluorophore which can be used for human NAD(P)H:quinone oxidoreductase (hNQO1) detection was developed. The probe, TPQ, which displays high selectivity and anti-interference ability, was successfully applied to endogenous hNQO1 imaging and for the identification of different cancer cells.",

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AU - Kwon, Nahyun

AU - Cho, Myoung Ki

AU - Park, Sang Jun

AU - Kim, Dayoung

AU - Nam, Sang Jip

AU - Cui, Lei

AU - Kim, Hwan Myung

AU - Yoon, Juyoung

PY - 2017

Y1 - 2017

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AB - A new quinone propionic acid locked TP fluorophore which can be used for human NAD(P)H:quinone oxidoreductase (hNQO1) detection was developed. The probe, TPQ, which displays high selectivity and anti-interference ability, was successfully applied to endogenous hNQO1 imaging and for the identification of different cancer cells.

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ER -

An efficient two-photon fluorescent probe for human NAD(P)H:quinone oxidoreductase (hNQO1) detection and imaging in tumor cells

Abstract

Bibliographical note

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