An Efficient Green Approach to Constructing Adenine Sulfate-Derived Multicolor Sulfur- and Nitrogen-Codoped Carbon Dots and Their Bioimaging Applications

Dinh Khoi Dang, Van Nghia Nguyen, Zeeshan Tahir, Hyunsun Jeong, Sungdo Kim, Hong Nhan Tran, Shinuk Cho, Yun Chang Park, Jong Seong Bae, Chinh Tam Le, Juyoung Yoon, Yong Soo Kim

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A cost-effective and environmentally friendly approach is proposed for producing N- and S-codoped multicolor-emission carbon dots (N- and S-codoped MCDs) at a mild reaction temperature (150 °C) and relatively short time (3 h). In this process, adenine sulfate acts as a novel precursor and doping agent, effectively reacting with other reagents such as citric acid, para-aminosalicylic acid, and ortho-phenylenediamine, even during solvent-free pyrolysis. The distinctive structures of reagents lead to the increased amount of graphitic nitrogen and sulfur doping in the N- and S-codoped MCDs. Notably, the obtained N- and S-codoped MCDs exhibit considerable fluorescence intensities, and their emission color can be adjusted from blue to yellow. The observed tunable photoluminescence can be attributed to variations in the surface state and the amount of N and S contents. Furthermore, due to the favorable optical properties, good water solubility and biocompatibility, and low cytotoxicity, these N- and S-codoped MCDs, especially green carbon dots, are successfully applied as fluorescent probes for bioimaging. The affordable and environmentally friendly synthesis method employed to create N- and S-codoped MCDs, combined with their remarkable optical properties, offers a promising avenue for their use in various fields, particularly in biomedical applications.

Original languageEnglish
Pages (from-to)32783-32791
Number of pages9
JournalACS Applied Materials and Interfaces
Volume15
Issue number27
DOIs
StatePublished - 12 Jul 2023

Bibliographical note

Publisher Copyright:
© 2023 American Chemical Society.

Keywords

  • S- and N-codoped
  • adenine sulfate
  • bioimaging applications
  • multicolor-emission carbon dots (MCDs)
  • solvent-free method

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