An aryl-thioether substituted nitrobenzothiadiazole probe for the selective detection of cysteine and homocysteine

Dayoung Lee; Gyoungmi Kim; Jun Yin; Juyoung Yoon

doi:10.1039/c5cc01071c

An aryl-thioether substituted nitrobenzothiadiazole probe for the selective detection of cysteine and homocysteine

Dayoung Lee, Gyoungmi Kim, Jun Yin, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

150 Scopus citations

Abstract

An aryl-thioether substituted nitrobenzothiadiazole probe was synthesized and employed to detect cysteine and homocysteine selectively in living cells. Interestingly, both cysteine (Cys) and homocysteine (Hcy) promote an enhancement of the fluorescence intensity of the probe at pH 7.4 while only Cys gives rise to this enhancement under weakly acidic conditions (pH 6.0).

Original language	English
Pages (from-to)	6518-6520
Number of pages	3
Journal	Chemical Communications
Volume	51
Issue number	30
DOIs	https://doi.org/10.1039/c5cc01071c
State	Published - 18 Apr 2015

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Publisher Copyright:
© The Royal Society of Chemistry 2015.

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abstract = "An aryl-thioether substituted nitrobenzothiadiazole probe was synthesized and employed to detect cysteine and homocysteine selectively in living cells. Interestingly, both cysteine (Cys) and homocysteine (Hcy) promote an enhancement of the fluorescence intensity of the probe at pH 7.4 while only Cys gives rise to this enhancement under weakly acidic conditions (pH 6.0).",

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AU - Kim, Gyoungmi

AU - Yin, Jun

AU - Yoon, Juyoung

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

PY - 2015/4/18

Y1 - 2015/4/18

N2 - An aryl-thioether substituted nitrobenzothiadiazole probe was synthesized and employed to detect cysteine and homocysteine selectively in living cells. Interestingly, both cysteine (Cys) and homocysteine (Hcy) promote an enhancement of the fluorescence intensity of the probe at pH 7.4 while only Cys gives rise to this enhancement under weakly acidic conditions (pH 6.0).

AB - An aryl-thioether substituted nitrobenzothiadiazole probe was synthesized and employed to detect cysteine and homocysteine selectively in living cells. Interestingly, both cysteine (Cys) and homocysteine (Hcy) promote an enhancement of the fluorescence intensity of the probe at pH 7.4 while only Cys gives rise to this enhancement under weakly acidic conditions (pH 6.0).

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An aryl-thioether substituted nitrobenzothiadiazole probe for the selective detection of cysteine and homocysteine

Abstract

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