An aniline bearing hemicyanine derivative serves as a mitochondria selective probe

Dayoung Lee; Min Kyo Jung; Jun Yin; Gyoungmi Kim; Chan Gi Pack; Juyoung Yoon

doi:10.1016/j.dyepig.2016.09.010

An aniline bearing hemicyanine derivative serves as a mitochondria selective probe

Dayoung Lee, Min Kyo Jung, Jun Yin, Gyoungmi Kim, Chan Gi Pack, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Mitochondria play key roles in a variety of pathologies, such as Alzheimer's disease and cancer. Because of this, the development of mitochondria staining probes has attracted great attention. In the current study, we designed, prepared and explored the properties of the hemicyanine derivative, HCA-Mito, bearing an aniline moiety. The results show that this substance serves as a mitochondria staining probe. HCA-Mito, which is insensitive to pH and has a low cytotoxicity, shows a high coincidence with the mitochondria specific dyes, MitoTracker Red and MitoTracker Deep Red. More importantly, the fibrous network structure of mitochondria is clearly stained by using HCA-Mito.

Original language	English
Pages (from-to)	467-472
Number of pages	6
Journal	Dyes and Pigments
Volume	136
DOIs	https://doi.org/10.1016/j.dyepig.2016.09.010
State	Published - 1 Jan 2017

Bibliographical note

Funding Information:
This study was supported by the gs1:National Research Foundation of Korea grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814 ). Mass spectral data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer.

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

Fluorescent probe
Fluorescent sensor
Mitochondria selective probe
Mitochondria staining probe

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dyepig.2016.09.010

Cite this

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title = "An aniline bearing hemicyanine derivative serves as a mitochondria selective probe",

abstract = "Mitochondria play key roles in a variety of pathologies, such as Alzheimer's disease and cancer. Because of this, the development of mitochondria staining probes has attracted great attention. In the current study, we designed, prepared and explored the properties of the hemicyanine derivative, HCA-Mito, bearing an aniline moiety. The results show that this substance serves as a mitochondria staining probe. HCA-Mito, which is insensitive to pH and has a low cytotoxicity, shows a high coincidence with the mitochondria specific dyes, MitoTracker Red and MitoTracker Deep Red. More importantly, the fibrous network structure of mitochondria is clearly stained by using HCA-Mito.",

keywords = "Fluorescent probe, Fluorescent sensor, Mitochondria selective probe, Mitochondria staining probe",

author = "Dayoung Lee and Jung, {Min Kyo} and Jun Yin and Gyoungmi Kim and Pack, {Chan Gi} and Juyoung Yoon",

note = "Funding Information: This study was supported by the gs1:National Research Foundation of Korea grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814 ). Mass spectral data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

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doi = "10.1016/j.dyepig.2016.09.010",

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AU - Lee, Dayoung

AU - Jung, Min Kyo

AU - Yin, Jun

AU - Kim, Gyoungmi

AU - Pack, Chan Gi

AU - Yoon, Juyoung

N1 - Funding Information: This study was supported by the gs1:National Research Foundation of Korea grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814 ). Mass spectral data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer. Publisher Copyright: © 2016 Elsevier Ltd

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Mitochondria play key roles in a variety of pathologies, such as Alzheimer's disease and cancer. Because of this, the development of mitochondria staining probes has attracted great attention. In the current study, we designed, prepared and explored the properties of the hemicyanine derivative, HCA-Mito, bearing an aniline moiety. The results show that this substance serves as a mitochondria staining probe. HCA-Mito, which is insensitive to pH and has a low cytotoxicity, shows a high coincidence with the mitochondria specific dyes, MitoTracker Red and MitoTracker Deep Red. More importantly, the fibrous network structure of mitochondria is clearly stained by using HCA-Mito.

AB - Mitochondria play key roles in a variety of pathologies, such as Alzheimer's disease and cancer. Because of this, the development of mitochondria staining probes has attracted great attention. In the current study, we designed, prepared and explored the properties of the hemicyanine derivative, HCA-Mito, bearing an aniline moiety. The results show that this substance serves as a mitochondria staining probe. HCA-Mito, which is insensitive to pH and has a low cytotoxicity, shows a high coincidence with the mitochondria specific dyes, MitoTracker Red and MitoTracker Deep Red. More importantly, the fibrous network structure of mitochondria is clearly stained by using HCA-Mito.

KW - Fluorescent probe

KW - Fluorescent sensor

KW - Mitochondria selective probe

KW - Mitochondria staining probe

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SN - 0143-7208

VL - 136

SP - 467

EP - 472

JO - Dyes and Pigments

JF - Dyes and Pigments

ER -

An aniline bearing hemicyanine derivative serves as a mitochondria selective probe

Abstract

Bibliographical note

Keywords

UN SDGs

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