An aniline bearing hemicyanine derivative serves as a mitochondria selective probe

Dayoung Lee, Min Kyo Jung, Jun Yin, Gyoungmi Kim, Chan Gi Pack, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Mitochondria play key roles in a variety of pathologies, such as Alzheimer's disease and cancer. Because of this, the development of mitochondria staining probes has attracted great attention. In the current study, we designed, prepared and explored the properties of the hemicyanine derivative, HCA-Mito, bearing an aniline moiety. The results show that this substance serves as a mitochondria staining probe. HCA-Mito, which is insensitive to pH and has a low cytotoxicity, shows a high coincidence with the mitochondria specific dyes, MitoTracker Red and MitoTracker Deep Red. More importantly, the fibrous network structure of mitochondria is clearly stained by using HCA-Mito.

Original languageEnglish
Pages (from-to)467-472
Number of pages6
JournalDyes and Pigments
Volume136
DOIs
StatePublished - 1 Jan 2017

Bibliographical note

Funding Information:
This study was supported by the gs1:National Research Foundation of Korea grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814 ). Mass spectral data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer.

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

  • Fluorescent probe
  • Fluorescent sensor
  • Mitochondria selective probe
  • Mitochondria staining probe

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