Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients

Byoung Seok Ye, Sang Won Seo, Geon Ha Kim, Young Noh, Hanna Cho, Cindy W. Yoon, Hee Jin Kim, Juhee Chin, Seun Jeon, Jong Min Lee, Joon Kyung Seong, Jae Seung Kim, Jae Hong Lee, Yearn Seong Choe, Kyung Han Lee, Young H. Sohn, Michael Ewers, Michael Weiner, Duk L. Na

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Background We investigated the independent effects of Alzheimer's disease (AD) and cerebrovascular disease (CVD) pathologies on brain structural changes and cognition. Methods Amyloid burden (Pittsburgh compound B [PiB] retention ratio), CVD markers (volume of white matter hyperintensities [WMH] and number of lacunae), and structural changes (cortical thickness and hippocampal shape) were measured in 251 cognitively impaired patients. Path analyses were utilized to assess the effects of these markers on cognition. Results PiB retention ratio was associated with hippocampal atrophy, which was associated with memory impairment. WMH were associated with frontal thinning, which was associated with executive and memory dysfunctions. PiB retention ratio and lacunae were also associated with memory and executive dysfunction without the mediation of hippocampal or frontal atrophy. Conclusions Our results suggest that the impacts of AD and CVD pathologies on cognition are mediated by specific brain regions.

Original languageEnglish
Pages (from-to)494-503.e3
JournalAlzheimer's and Dementia
Issue number5
StatePublished - 1 May 2015

Bibliographical note

Funding Information:
The authors would like to thank Victoria Barney for English correction. The authors also want to give special thanks to Changsoo Kim for his statistical advice. This study was supported by Basic Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( NRF-2013R1A1A2065365 ), the Korean Healthcare Technology R&D Project Ministry for Health & Welfare Affairs ( HI10C2020 & HIC120713 ), the KOSEF NRL program grant (MEST; 2011-0028333 ), Samsung Medical Center ( CRL-108011 & CRS110-14-1 ), and the Converging Research Center Program through the Ministry of Science, ICT and Future Planning, Korea ( 2013K000338 ).

Publisher Copyright:
© 2015 The Alzheimer's Association.


  • Amyloid
  • Atrophy
  • Cerebrovascular disease
  • Cognition
  • Cortical thickness
  • Hippocampus
  • Path analysis
  • Pittsburgh compound B


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