Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging

Dong Eun Lee; Ah Young Kim; Hong Yeol Yoon; Ki Young Choi; Ick Chan Kwon; Seo Young Jeong; Jae Hyung Park; Kwangmeyung Kim

doi:10.1039/c2jm31406a

Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging

Dong Eun Lee, Ah Young Kim, Hong Yeol Yoon, Ki Young Choi, Ick Chan Kwon, Seo Young Jeong, Jae Hyung Park, Kwangmeyung Kim

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The amphiphilic hyaluronic acid-5β-cholanic acid (HA-CA) conjugates were synthesized to fabricate near-infrared fluorescence (NIRF) dye conjugated and water-dispersible SPION-encapsulated hyaluronic acid nanoparticles (HNPs) for a tumor-targeted optical and magnetic resonance (MR) dual imaging contrast agent. Notably, HNPs were preferentially accumulated in the tumor region, implying that the hydrophilic HA shells of nanoparticles allow prolonged circulation and excellent active targeting of the SPION encapsulated nanoparticles in tumor-bearing mice.

Original language	English
Pages (from-to)	10444-10447
Number of pages	4
Journal	Journal of Materials Chemistry
Volume	22
Issue number	21
DOIs	https://doi.org/10.1039/c2jm31406a
State	Published - 7 Jun 2012

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title = "Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging",

abstract = "The amphiphilic hyaluronic acid-5β-cholanic acid (HA-CA) conjugates were synthesized to fabricate near-infrared fluorescence (NIRF) dye conjugated and water-dispersible SPION-encapsulated hyaluronic acid nanoparticles (HNPs) for a tumor-targeted optical and magnetic resonance (MR) dual imaging contrast agent. Notably, HNPs were preferentially accumulated in the tumor region, implying that the hydrophilic HA shells of nanoparticles allow prolonged circulation and excellent active targeting of the SPION encapsulated nanoparticles in tumor-bearing mice.",

author = "Lee, {Dong Eun} and Kim, {Ah Young} and Yoon, {Hong Yeol} and Choi, {Ki Young} and Kwon, {Ick Chan} and Jeong, {Seo Young} and Park, {Jae Hyung} and Kwangmeyung Kim",

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doi = "10.1039/c2jm31406a",

language = "English",

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T1 - Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging

AU - Lee, Dong Eun

AU - Kim, Ah Young

AU - Yoon, Hong Yeol

AU - Choi, Ki Young

AU - Kwon, Ick Chan

AU - Jeong, Seo Young

AU - Park, Jae Hyung

AU - Kim, Kwangmeyung

PY - 2012/6/7

Y1 - 2012/6/7

N2 - The amphiphilic hyaluronic acid-5β-cholanic acid (HA-CA) conjugates were synthesized to fabricate near-infrared fluorescence (NIRF) dye conjugated and water-dispersible SPION-encapsulated hyaluronic acid nanoparticles (HNPs) for a tumor-targeted optical and magnetic resonance (MR) dual imaging contrast agent. Notably, HNPs were preferentially accumulated in the tumor region, implying that the hydrophilic HA shells of nanoparticles allow prolonged circulation and excellent active targeting of the SPION encapsulated nanoparticles in tumor-bearing mice.

AB - The amphiphilic hyaluronic acid-5β-cholanic acid (HA-CA) conjugates were synthesized to fabricate near-infrared fluorescence (NIRF) dye conjugated and water-dispersible SPION-encapsulated hyaluronic acid nanoparticles (HNPs) for a tumor-targeted optical and magnetic resonance (MR) dual imaging contrast agent. Notably, HNPs were preferentially accumulated in the tumor region, implying that the hydrophilic HA shells of nanoparticles allow prolonged circulation and excellent active targeting of the SPION encapsulated nanoparticles in tumor-bearing mice.

UR - http://www.scopus.com/inward/record.url?scp=84862670555&partnerID=8YFLogxK

U2 - 10.1039/c2jm31406a

DO - 10.1039/c2jm31406a

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VL - 22

SP - 10444

EP - 10447

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 21

ER -

Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging

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