Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging

Dong Eun Lee, Ah Young Kim, Hong Yeol Yoon, Ki Young Choi, Ick Chan Kwon, Seo Young Jeong, Jae Hyung Park, Kwangmeyung Kim

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The amphiphilic hyaluronic acid-5β-cholanic acid (HA-CA) conjugates were synthesized to fabricate near-infrared fluorescence (NIRF) dye conjugated and water-dispersible SPION-encapsulated hyaluronic acid nanoparticles (HNPs) for a tumor-targeted optical and magnetic resonance (MR) dual imaging contrast agent. Notably, HNPs were preferentially accumulated in the tumor region, implying that the hydrophilic HA shells of nanoparticles allow prolonged circulation and excellent active targeting of the SPION encapsulated nanoparticles in tumor-bearing mice.

Original languageEnglish
Pages (from-to)10444-10447
Number of pages4
JournalJournal of Materials Chemistry
Issue number21
StatePublished - 7 Jun 2012


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