Ameliorating effects of Mango (Mangifera indica L.) fruit on plasma ethanol level in a mouse model assessed with 1H-NMR based metabolic profiling

So Hyun Kim, Somi K. Cho, Tae Sun Min, Yujin Kim, Seung Ok Yang, Hee Su Kim, Sun Hee Hyun, Hana Kim, Young Suk Kim, Hyung Kyoon Choi

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The ameliorating effects of Mango (Mangifera indica L.) flesh and peel samples on plasma ethanol level were investigated using a mouse model. Mango fruit samples remarkably decreased mouse plasma ethanol levels and increased the activities of alcohol dehydrogenase and acetaldehyde dehydrogenase. The 1H-NMR-based metabolomic technique was employed to investigate the differences in metabolic profiles of mango fruits, and mouse plasma samples fed with mango fruit samples. The partial least squares-discriminate analysis of 1H-NMR spectral data of mouse plasma demonstrated that there were clear separations among plasma samples from mice fed with buffer, mango flesh and peel. A loading plot demonstrated that metabolites from mango fruit, such as fructose and aspartate, might stimulate alcohol degradation enzymes. This study suggests that mango flesh and peel could be used as resources for functional foods intended to decrease plasma ethanol level after ethanol uptake.

Original languageEnglish
Pages (from-to)214-221
Number of pages8
JournalJournal of Clinical Biochemistry and Nutrition
Volume48
Issue number3
DOIs
StatePublished - May 2011

Keywords

  • H-NMR
  • Mangifera indica
  • Mango
  • Metabolomics
  • Plasma ethanol level

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