Altered intrinsic brain activity after chemotherapy in patients with gastric cancer: A preliminary study

Hyun Gi Kim, Na Young Shin, Yunjin Bak, Kyung Ran Kim, Young Chul Jung, Kyunghwa Han, Seung Koo Lee, Soo Mee Lim

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Objectives: To characterize the pattern of altered intrinsic brain activity in gastric cancer patients after chemotherapy (CTx). Methods: Patients before and after CTx (n = 14) and control subjects (n = 11) underwent resting-state functional MRI (rsfMRI) at baseline and 3 months after CTx. Regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between the groups using the two-sample t test. Correlation analysis was also performed between rsfMRI values (i.e., ReHo, ALFF, and fALFF) and neuropsychological test results. Results: Patients showed poor performance in verbal memory and executive function and decreased rsfMRI values in the frontal areas even before CTx and showed decreased attention/working memory and executive function after CTx compared to the control subjects. In direct comparison of values before and after CTx, there were no significant differences in neuropsychological test scores, but decreased rsfMRI values were observed at the frontal lobes and right cerebellar region. Among rsfMRI values, lower ALFF in the left inferior frontal gyrus was significantly associated with poor performance of the executive function test. Conclusions: We observed decreased attention/working memory and executive function that corresponded to the decline of frontal region activation in gastric cancer patients who underwent CTx. Key Points: • Intrinsic brain activity of gastric cancer patients after chemotherapy was described. • Brain activity and neuropsychological test results were correlated. • Working memory and executive function decreased after chemotherapy. • Decreased cognitive function corresponded to decreased activation of the frontal region.

Original languageEnglish
Pages (from-to)2679-2688
Number of pages10
JournalEuropean Radiology
Issue number7
StatePublished - 1 Jul 2017

Bibliographical note

Funding Information:
The scientific guarantor of this publication is Na-Young Shin. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This work was supported by the Ewha Womans University Research Grant of 2015 (1-2015-0437-001-1). One of the authors has significant statistical expertise (Kyunghwa Han). Institutional review board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: prospective, case-control study, performed at one institution.

Publisher Copyright:
© 2017, European Society of Radiology.


  • Brain
  • Cancer chemotherapy agents
  • Cognitive function
  • Functional magnetic resonance imaging
  • Gastric cancer


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