Altered cingulate white matter connectivity in panic disorder patients

Doug Hyun Han, Perry F. Renshaw, Stephen R. Dager, Ain Chung, Jaeuk Hwang, Melissa A. Daniels, Young Sik Lee, In Kyoon Lyoo

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Objective: Functional imaging studies of panic disorder subjects suggest an increased activation of the cingulate regions of the brain. Aim of the current study was to explore the white matter connectivity differences between subjects with panic disorder and healthy comparison subjects. Method: Structural white matter connectivity, as determined from fractional anisotropy (FA) values obtained by diffusion tensor imaging, was assessed for anterior and posterior cingulate regions in 24 panic disorder patients and 24 age and sex-matched healthy comparison subjects. Results: Subjects with panic disorder exhibited significantly greater FA values in left anterior and right posterior cingulate regions (by 13.3% and 19.6%, respectively) relative to comparison subjects. White matter connectivity for these two cingulate regions was also positively correlated with clinical severity, as determined by Panic Disorder Severity Scale. FA values in left anterior cingulate region negatively correlated with the time of Trail Making Tests and positively with Digit Symbol Substitution Test. Conclusions: Findings suggest a potential 'enhancement' in white matter connectivity in left anterior and right posterior cingulate regions in panic disorder, and that these changes may play an important role in mediating clinical symptoms of panic disorder.

Original languageEnglish
Pages (from-to)399-407
Number of pages9
JournalJournal of Psychiatric Research
Issue number5
StatePublished - Apr 2008

Bibliographical note

Funding Information:
This study was supported by grants from the Korea Health 21 R&D Project (A06-0434-A21018-06N1-00010A) funded by Ministry of Health & Welfare; Brain Research Center of the 21st Century Frontier Research Program (M103KV010022-06K2201-02210) funded by the Ministry of Science and Technology, the Republic of Korea (70%), the Seoul National University Hospital Grant (04-2006-066-0) and 2006 NARSAD Independent Investigator Award (Great Neck, NY, USA; I.K.L.).


  • Cingulate
  • Diffusion tensor imaging
  • Panic disorder


Dive into the research topics of 'Altered cingulate white matter connectivity in panic disorder patients'. Together they form a unique fingerprint.

Cite this