Aloe-derived nanovesicles attenuate inflammation and enhance tight junction proteins for acute colitis treatment

Sang Hun Choi, Jung Young Eom, Hyun Jin Kim, Wonhyo Seo, Hyo Jung Kwun, Do Kyun Kim, Jihoon Kim, Young Eun Cho

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Inflammatory bowel disease (IBD) is a chronic recurrent inflammatory disease of the digestive tract that causes pain and weight loss and also increases the risk of colon cancer. Inspired by the benefits of plant-derived nanovesicles and aloe, we herein report aloe-derived nanovesicles, including aloe vera-derived nanovesicles (VNVs), aloe arborescens-derived nanovesicles (ANVs), and aloe saponaria-derived nanovesicles (SNVs) and evaluate their therapeutic potential and molecular mechanisms in a dextran sulfate sodium (DSS)-induced acute experimental colitis mouse model. Aloe-derived nanovesicles not only facilitate markedly reduced DSS-induced acute colonic inflammation, but also enable the restoration of tight junction (TJ) and adherent junction (AJ) proteins to prevent gut permeability in DSS-induced acute colonic injury. These therapeutic effects are ascribed to the anti-inflammatory and anti-oxidant effects of aloe-derived nanovesicles. Therefore, aloe-derived nanovesicles are a safe treatment option for IBD.

Original languageEnglish
Pages (from-to)5490-5501
Number of pages12
JournalBiomaterials Science
Volume11
Issue number16
DOIs
StatePublished - 21 Jun 2023

Bibliographical note

Publisher Copyright:
© 2023 The Royal Society of Chemistry.

Fingerprint

Dive into the research topics of 'Aloe-derived nanovesicles attenuate inflammation and enhance tight junction proteins for acute colitis treatment'. Together they form a unique fingerprint.

Cite this