Aliphatic hydroxylation by a bis(μ-oxo)dicopper(III) complex

Shinobu Itoh; Masayasu Taki; Hajime Nakao; Patrick L. Holland; William B. Tolman; Lawrence Que; Shunichi Fukuzumi

doi:10.1002/(SICI)1521-3773(20000117)39:2<398::AID-ANIE398>3.0.CO;2-2

Aliphatic hydroxylation by a bis(μ-oxo)dicopper(III) complex

Shinobu Itoh, Masayasu Taki, Hajime Nakao, Patrick L. Holland, William B. Tolman, Lawrence Que, Shunichi Fukuzumi

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

By using molecular oxygen bis(μ-oxo)dicopper(III) complexes can be produced from Cu¹ complexes with ligand L(X) (L(X) = p-substituted N-ethyl- N-[2-(2-pyridyl)ethyl]-2-phenylethylamine; X = OMe, Me, H, Cl, NO₂) in which the benzylic position of the ligand is activated and hydroxylated by the Cu₂O₂ core (see reaction scheme). Detailed characterization of this new C-H bond activation reaction by the bis(μ-oxo)dicopper(III) core reveals important information on the fundamental chemistry underlying copper monooxygenase reactivity.

Original language	English
Pages (from-to)	398-400
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	39
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1521-3773(20000117)39:2<398::AID-ANIE398>3.0.CO;2-2
State	Published - 17 Jan 2000

Keywords

C-H activation
Copper
Hydroxylations
O ligands
O-O activation

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10.1002/(SICI)1521-3773(20000117)39:2<398::AID-ANIE398>3.0.CO;2-2

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abstract = "By using molecular oxygen bis(μ-oxo)dicopper(III) complexes can be produced from Cu1 complexes with ligand L(X) (L(X) = p-substituted N-ethyl- N-[2-(2-pyridyl)ethyl]-2-phenylethylamine; X = OMe, Me, H, Cl, NO2) in which the benzylic position of the ligand is activated and hydroxylated by the Cu2O2 core (see reaction scheme). Detailed characterization of this new C-H bond activation reaction by the bis(μ-oxo)dicopper(III) core reveals important information on the fundamental chemistry underlying copper monooxygenase reactivity.",

keywords = "C-H activation, Copper, Hydroxylations, O ligands, O-O activation",

author = "Shinobu Itoh and Masayasu Taki and Hajime Nakao and Holland, {Patrick L.} and Tolman, {William B.} and Lawrence Que and Shunichi Fukuzumi",

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T1 - Aliphatic hydroxylation by a bis(μ-oxo)dicopper(III) complex

AU - Itoh, Shinobu

AU - Taki, Masayasu

AU - Nakao, Hajime

AU - Holland, Patrick L.

AU - Tolman, William B.

AU - Que, Lawrence

AU - Fukuzumi, Shunichi

PY - 2000/1/17

Y1 - 2000/1/17

N2 - By using molecular oxygen bis(μ-oxo)dicopper(III) complexes can be produced from Cu1 complexes with ligand L(X) (L(X) = p-substituted N-ethyl- N-[2-(2-pyridyl)ethyl]-2-phenylethylamine; X = OMe, Me, H, Cl, NO2) in which the benzylic position of the ligand is activated and hydroxylated by the Cu2O2 core (see reaction scheme). Detailed characterization of this new C-H bond activation reaction by the bis(μ-oxo)dicopper(III) core reveals important information on the fundamental chemistry underlying copper monooxygenase reactivity.

AB - By using molecular oxygen bis(μ-oxo)dicopper(III) complexes can be produced from Cu1 complexes with ligand L(X) (L(X) = p-substituted N-ethyl- N-[2-(2-pyridyl)ethyl]-2-phenylethylamine; X = OMe, Me, H, Cl, NO2) in which the benzylic position of the ligand is activated and hydroxylated by the Cu2O2 core (see reaction scheme). Detailed characterization of this new C-H bond activation reaction by the bis(μ-oxo)dicopper(III) core reveals important information on the fundamental chemistry underlying copper monooxygenase reactivity.

KW - C-H activation

KW - Copper

KW - Hydroxylations

KW - O ligands

KW - O-O activation

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Aliphatic hydroxylation by a bis(μ-oxo)dicopper(III) complex

Abstract

Keywords

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