Albumin-mediated “Unlocking” of supramolecular prodrug-like nanozymes toward selective imaging-guided phototherapy

Jingjing Han, Haidong Li, Luyang Zhao, Gyoungmi Kim, Yahui Chen, Xuehai Yan, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Construction of an activatable photosensitizer and integration into an adaptive nanozyme during phototherapy without producing off-target toxicity remains a challenge. Herein, we have fabricated a prodrug-like supramolecular nanozyme based on a metallic-curcumin and cyanine co-assembly. The albumin-mediated phenol AOH group transformation of nanozyme changes its adjustable oxygen stress from negative superoxide dismutase-like activity of ROS-scavenging to positive photo oxidase activity with an ROS-amplifying capacity. It further increases the depth penetration of a nanozyme in a tumor spheroid, selectively targeting tumorous phototherapy. It also triggers a signal in targeted tumor cells and helps increase cancer cell ablation. This work suggests new options for development of activatable supramolecular nanozymes and provides a synergetic prodrug-like nanozyme strategy for early diagnosis and preclinical phototherapeutics.

Original languageEnglish
Pages (from-to)7814-7820
Number of pages7
JournalChemical Science
Volume13
Issue number26
DOIs
StatePublished - 6 Jun 2022

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2022R1A2C3005420). X. Yan is grateful for financial support from the National Natural Science Foundation of China (Project No. 22025207, 21977095, and 22077122). H. Li thanks the Fundamental Research Funds for the Central Universities (No. DUT22RC(3)025) for financial support. We also thanks for ESI-MS, KBSI (Korea Basic Science Institute) Ochang results.

Publisher Copyright:
© 2022 The Royal Society of Chemistry.

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