Agmatine, an amine and organic cation, reduced H2O2 that was generated by hyperglycemia, and transcription factors such as NF-κB and AP-1 activity in the mesangial cells that were exposed to high glucose. However, spermine which shares a strong nucleophilic structure with agmatine decreased the H2O2 levels and AP-1, but not the NF-κB activity. Possible roles for agmatine and spermine in decreasing fibronectin are discussed, and the signaling pathway for agmatine-reduced fibronectin accumulation is presented.
|Number of pages||7|
|Journal||Journal of Biochemistry and Molecular Biology|
|State||Published - 31 May 2003|
- Hydrogen peroxide