Abstract
Agmatine, an amine and organic cation, reduced H2O2 that was generated by hyperglycemia, and transcription factors such as NF-κB and AP-1 activity in the mesangial cells that were exposed to high glucose. However, spermine which shares a strong nucleophilic structure with agmatine decreased the H2O2 levels and AP-1, but not the NF-κB activity. Possible roles for agmatine and spermine in decreasing fibronectin are discussed, and the signaling pathway for agmatine-reduced fibronectin accumulation is presented.
Original language | English |
---|---|
Pages (from-to) | 251-257 |
Number of pages | 7 |
Journal | Journal of Biochemistry and Molecular Biology |
Volume | 36 |
Issue number | 3 |
DOIs | |
State | Published - 31 May 2003 |
Keywords
- AP-1
- Agmatine
- Fibronectin
- Hydrogen peroxide
- NF-κB