Agmatine reduces hydrogen peroxide in mesangial cells under high glucose conditions

Geun Taek Lee, Hunjoo Ha, Hyun Chul Lee, Young Dong Cho

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Agmatine, an amine and organic cation, reduced H2O2 that was generated by hyperglycemia, and transcription factors such as NF-κB and AP-1 activity in the mesangial cells that were exposed to high glucose. However, spermine which shares a strong nucleophilic structure with agmatine decreased the H2O2 levels and AP-1, but not the NF-κB activity. Possible roles for agmatine and spermine in decreasing fibronectin are discussed, and the signaling pathway for agmatine-reduced fibronectin accumulation is presented.

Original languageEnglish
Pages (from-to)251-257
Number of pages7
JournalJournal of Biochemistry and Molecular Biology
Volume36
Issue number3
DOIs
StatePublished - 31 May 2003

Keywords

  • AP-1
  • Agmatine
  • Fibronectin
  • Hydrogen peroxide
  • NF-κB

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