AgInS2-Coated Upconversion Nanoparticle as a Photocatalyst for Near-Infrared Light-Activated Photodynamic Therapy of Cancer Cells

Swarup Kumar Maji, Dong Ha Kim

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The development of high-performance near-infrared (NIR) photocatalysts with long-term stability and the elucidation on the working mechanism along with multifunctional activity toward biomedical applications have not been explored sufficiently. Herein, a novel hybrid material of an upconversion nanoparticle (NaYF4/Yb3+,Er3+) (UCN) coated with a ternary semiconductor (AgInS2, AIS) has been synthesized by a simple and robust two-step solvothermal route for NIR light active photocatalysis. Preparation of oleic acid-capped spherical UC nanoparticles (NPs) (â25 nm) followed by solvothermal decomposition of two precursor complexes Ag(acda) and In(acda)3 resulted in the formation of well-defined NaYF4/Yb3+,Er3+@AgInS2 core-shell nanoparticles (UCN@AIS NPs) (â90 nm). It has been found that effective energy transfer occurred from NaYF4/Yb3+,Er3+ to AgInS2 by a nonradiative luminescence resonance energy transfer process. Superior photocatalytic decomposition activity was validated in terms of the degradation of methylene blue dye under the exposure of 980 nm NIR laser light with the presence of a UCN@AIS NP catalyst. The degradation process was mediated primarily owing to the formation of a cytotoxic reactive oxygen species (ROS) by the hybrid material under NIR light irradiation, in which UCN performs as a transducer to sensitize AIS and trigger the ROS generation. In vitro cancer cell imaging potentiality of the UCN@AIS NPs was then studied on cervical cancer cells (HeLa cells). The UCN@AIS NPs induced in vitro cervical cancer cell death (photodynamic therapy) with â27% efficiency as measured by the MTT assay and thus proved to be a decent candidate for NIR active photocatalysts for biomedical applications.

Original languageEnglish
Pages (from-to)1628-1638
Number of pages11
JournalACS Applied Bio Materials
Volume1
Issue number5
DOIs
StatePublished - 19 Nov 2018

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government (2017R1A2A1A05022387) and by the Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2018M3D1A1058536). S.K.M. is thankful to Khatra Adibasi Mahavidyalaya India, (KAM) for supporting the research programme for faculty quality improvement. S.K.M. is also thankful to the Department of Higher Education Science and Technology & Biotechnology, Government of West Bengal India, for granting special study leave from his academic position (KAM).

Funding Information:
This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government (2017R1A2A1A05022387) and by the Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2018M3D1A1058536). S.K.M. is thankful to Khatra Adibasi Mahavidyalaya, India, (KAM) for supporting the research programme for faculty quality improvement. S.K.M. is also thankful to the Department of Higher Education, Science and Technology & Biotechnology, Government of West Bengal, India, for granting special study leave from his academic position (KAM).

Publisher Copyright:
Copyright © 2018 American Chemical Society.

Keywords

  • bioimaging
  • near-infrared photocatalysis
  • photodynamic therapy
  • ternary semiconductor (AgInS)
  • upconversion nanoparticle

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