Aggressive natural killer cell leukemia: Is Epstein-Barr virus negativity an indicator of a favorable prognosis?

Young Hyeh Ko, Sanghui Park, Kihyun Kim, Seok Jin Kim, Won Seog Kim

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Aggressive natural killer (NK) cell leukemia (ANKL) is a prototype of an Epstein-Barr virus (EBV)-associated lymphoid malignancy, which is characterized by a fulminant clinical course and a median survival interval <2 months. EBV negativity in ANKL is uncommon, and the characteristics of EBV-negative ANKL are not well defined. We compared the clinicopathological characteristics of EBV-negative ANKL patients (group 1, n = 2) with those of EBV-positive ANKL patients (group 2, n = 14) and reviewed the literature for reports on EBV-negative ANKL cases. EBV-negative and EBV-positive ANKL patients had similar clinical and pathological characteristics, but EBV-negative patients had a longer survival than EBV-positive patients (11.5 vs. 1.5 months, respectively). EBV-negative patients achieved complete remission, but tumors often relapsed after a short interval. In conclusion, EBV-negative ANKL is an uncommon malignancy that pursues a less aggressive clinical course than EBV-positive ANKL.

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalActa Haematologica
Volume120
Issue number4
DOIs
StatePublished - Mar 2009

Keywords

  • Aggressive natural killer cell leukemia
  • Epstein-Barr virus
  • Leukemia
  • Lymphoproliferative disorders
  • Natural killer cells

Fingerprint

Dive into the research topics of 'Aggressive natural killer cell leukemia: Is Epstein-Barr virus negativity an indicator of a favorable prognosis?'. Together they form a unique fingerprint.

Cite this