Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine

Yanhong Duo, Lei Han, Yaoqiang Yang, Zhifeng Wang, Lirong Wang, Jingyi Chen, Zhongyuan Xiang, Juyoung Yoon, Guanghong Luo, Ben Zhong Tang

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Biopsy, including tissue and liquid biopsy, offers comprehensive and real-time physiological and pathological information for disease detection, diagnosis, and monitoring. Fluorescent probes are frequently selected to obtain adequate information on pathological processes in a rapid and minimally invasive manner based on their advantages for biopsy. However, conventional fluorescent probes have been found to show aggregation-caused quenching (ACQ) properties, impeding greater progresses in this area. Since the discovery of aggregation-induced emission luminogen (AIEgen) have promoted rapid advancements in molecular bionanomaterials owing to their unique properties, including high quantum yield (QY) and signal-to-noise ratio (SNR), etc. This review seeks to present the latest advances in AIEgen-based biofluorescent probes for biopsy in real or artificial samples, and also the key properties of these AIE probes. This review is divided into: (i) tissue biopsy based on smart AIEgens, (ii) blood sample biopsy based on smart AIEgens, (iii) urine sample biopsy based on smart AIEgens, (iv) saliva sample biopsy based on smart AIEgens, (v) biopsy of other liquid samples based on smart AIEgens, and (vi) perspectives and conclusion. This review could provide additional guidance to motivate interest and bolster more innovative ideas for further exploring the applications of various smart AIEgens in precision medicine.

Original languageEnglish
Pages (from-to)11242-11347
Number of pages106
JournalChemical Reviews
Volume124
Issue number20
DOIs
StatePublished - 23 Oct 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Published by American Chemical Society.

Fingerprint

Dive into the research topics of 'Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine'. Together they form a unique fingerprint.

Cite this