Advances in Application of Azobenzene as a Trigger in Biomedicine: Molecular Design and Spontaneous Assembly

Hong Bo Cheng, Shuchun Zhang, Ji Qi, Xing Jie Liang, Juyoung Yoon

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Azobenzene is a well-known derivative of stimulus-responsive molecular switches and has shown superior performance as a functional material in biomedical applications. The results of multiple studies have led to the development of light/hypoxia-responsive azobenzene for biomedical use. In recent years, long-wavelength-responsive azobenzene has been developed. Matching the longer wavelength absorption and hypoxia-response characteristics of the azobenzene switch unit to the bio-optical window results in a large and effective stimulus response. In addition, azobenzene has been used as a hypoxia-sensitive connector via biological cleavage under appropriate stimulus conditions. This has resulted in on/off state switching of properties such as pharmacology and fluorescence activity. Herein, recent advances in the design and fabrication of azobenzene as a trigger in biomedicine are summarized.

Original languageEnglish
Article number2007290
JournalAdvanced Materials
Volume33
Issue number26
DOIs
StatePublished - 1 Jul 2021

Keywords

  • azobenzene
  • bio-optical windows
  • biomedicine
  • hypoxia
  • photoswitches

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