@article{e55a2dfc7cdc40299835ba903981e15d,
title = "Advances in Application of Azobenzene as a Trigger in Biomedicine: Molecular Design and Spontaneous Assembly",
abstract = "Azobenzene is a well-known derivative of stimulus-responsive molecular switches and has shown superior performance as a functional material in biomedical applications. The results of multiple studies have led to the development of light/hypoxia-responsive azobenzene for biomedical use. In recent years, long-wavelength-responsive azobenzene has been developed. Matching the longer wavelength absorption and hypoxia-response characteristics of the azobenzene switch unit to the bio-optical window results in a large and effective stimulus response. In addition, azobenzene has been used as a hypoxia-sensitive connector via biological cleavage under appropriate stimulus conditions. This has resulted in on/off state switching of properties such as pharmacology and fluorescence activity. Herein, recent advances in the design and fabrication of azobenzene as a trigger in biomedicine are summarized.",
keywords = "azobenzene, bio-optical windows, biomedicine, hypoxia, photoswitches",
author = "Cheng, {Hong Bo} and Shuchun Zhang and Ji Qi and Liang, {Xing Jie} and Juyoung Yoon",
note = "Funding Information: H.B.C. was supported by Fundamental Research Funds for the Central Universities (buctrc202004) and the National Natural Science Foundation of China (21502195). This work was supported by the National Natural Science Foundation of China (NSFC) key projects (Grant Nos. 31630027 and 32030060) and NSFC‐German Research Foundation (DFG) project (Grant No. 31761133013). The authors also appreciate the support by “the Beijing‐Tianjin‐Hebei Basic Research Cooperation Project” (19JCZDJC64100), “Ten Thousand Elite Plan” (Grant No.Y9E21Z11) and CAS international collaboration plan (Grant No. E0632911ZX) as well as National Key Research & Development Program of China (Grant No. 2018YFE0117800). J.Y. was supported by a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (Grant No. 2012R1A3A2048814). Funding Information: H.B.C. was supported by Fundamental Research Funds for the Central Universities (buctrc202004) and the National Natural Science Foundation of China (21502195). This work was supported by the National Natural Science Foundation of China (NSFC) key projects (Grant Nos. 31630027 and 32030060) and NSFC-German Research Foundation (DFG) project (Grant No. 31761133013). The authors also appreciate the support by ?the Beijing-Tianjin-Hebei Basic Research Cooperation Project? (19JCZDJC64100), ?Ten Thousand Elite Plan? (Grant No.Y9E21Z11) and CAS international collaboration plan (Grant No. E0632911ZX) as well as National Key Research & Development Program of China (Grant No. 2018YFE0117800). J.Y. was supported by a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (Grant No. 2012R1A3A2048814). Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH",
year = "2021",
month = jul,
day = "1",
doi = "10.1002/adma.202007290",
language = "English",
volume = "33",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley-Blackwell",
number = "26",
}