Adult T-cell leukemia/lymphoma with features of CD30-positive anaplastic large cell lymphoma - A case report

Soon Nam Lee, Eunmi Nam, Ju Hyun Cha, Mi Jung Kim, Heasoo Koo, Sung Won Kwon, Hae Jin Park, Kyu Kwang Whang, Seok Il Hong

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8 Scopus citations

Abstract

We experienced a 58-year-old Korean man with adult T-cell leukemia/ lymphoma with features of histologically anaplastic large cell lymphoma involving the skin and testis. The patient had cutaneous nodules in both extremities and a palpable right testicular mass. Right orchiectomy was performed and specimens of removed testicle and skin nodules showed immunohistologically anaplastic large cell lymphoma with T-cell phenotype, and CD30 antigen was positive. A human T-cell lymphotropic virus type 1 (HTLV-1) antibody titer was over 1 : 256 and integration of HTLV-1 proviral DNA pX gene was identified in the peripheral blood mononuclear cells and lymphoma tissue by polymerase chain reaction. Peripheral blood and bone marrow did not show any evidence of characteristic neoplastic T-cells.

Original languageEnglish
Pages (from-to)364-368
Number of pages5
JournalJournal of Korean Medical Science
Volume12
Issue number4
DOIs
StatePublished - 1997

Keywords

  • Adult T-cell leukemia/lymphoma
  • Anaplastic large cell lymphoma (Ki-1 lymphoma)
  • Human T-cell lymphotropic virus type 1(HTLV-1)

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