Administration of glucosylceramide ameliorated the memory impairment in aged mice

Yeonju Lee, Sergiy Oliynyk, Jae Chul Jung, Jeong Jun Han, Seikwan Oh

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The function and the role of glucosylceramide have not been well studied in the central nervous system. This study was aimed to investigate the possible roles of glucosylceramide in memory function in aged mice. Glucosylceramide (50 mg/kg, p.o.) showed memory enhancing activity after 3-month treatment in the aged mice (C56BL/6, 18-20 months old) through Y-maze, novel objective test, and Morris water maze test. Long-term treatment of glucosylceramide decreased the expression of iNOS and COX-2 in the brain of aged mice. The LPS-induced mRNA level of iNOS, COX-2, IL-1β, and TNF-α was reduced by the acute treatment with glucosylceramide in adult mice. These results suggest that glucosylceramide plays an important role in anti-inflammatory and memory enhancement, and it could be a potential new therapeutic agent for the treatment of neurodegenerative diseases such as Alzheimer's disease.

Original languageEnglish
Article number824120
JournalEvidence-based Complementary and Alternative Medicine
StatePublished - 2013


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