Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy

Kyuri Lee, Soo Young Kim, Yunmi Seo, Myung Hee Kim, Jun Chang, Hyukjin Lee

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

For mRNA mediated cancer immunotherapy, Pam3 was incorporated as an adjuvant within lipid nanoparticles (LNPs) with OVA mRNA. The developed Pam3 incorporated LNPs showed successful expression of tumor antigens with enhanced immune stimulation. We demonstrated that the synergies of Pam3 LNPs could greatly improve the efficacy of tumor prevention by mRNA vaccines.

Original languageEnglish
Pages (from-to)1101-1105
Number of pages5
JournalBiomaterials Science
Volume8
Issue number4
DOIs
StatePublished - 21 Feb 2020

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