Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy

Kyuri Lee; Soo Young Kim; Yunmi Seo; Myung Hee Kim; Jun Chang; Hyukjin Lee

doi:10.1039/c9bm01564g

Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy

Kyuri Lee, Soo Young Kim, Yunmi Seo, Myung Hee Kim, Jun Chang, Hyukjin Lee

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

For mRNA mediated cancer immunotherapy, Pam3 was incorporated as an adjuvant within lipid nanoparticles (LNPs) with OVA mRNA. The developed Pam3 incorporated LNPs showed successful expression of tumor antigens with enhanced immune stimulation. We demonstrated that the synergies of Pam3 LNPs could greatly improve the efficacy of tumor prevention by mRNA vaccines.

Original language	English
Pages (from-to)	1101-1105
Number of pages	5
Journal	Biomaterials Science
Volume	8
Issue number	4
DOIs	https://doi.org/10.1039/c9bm01564g
State	Published - 21 Feb 2020

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2020.

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10.1039/c9bm01564g

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title = "Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy",

abstract = "For mRNA mediated cancer immunotherapy, Pam3 was incorporated as an adjuvant within lipid nanoparticles (LNPs) with OVA mRNA. The developed Pam3 incorporated LNPs showed successful expression of tumor antigens with enhanced immune stimulation. We demonstrated that the synergies of Pam3 LNPs could greatly improve the efficacy of tumor prevention by mRNA vaccines.",

author = "Kyuri Lee and Kim, {Soo Young} and Yunmi Seo and Kim, {Myung Hee} and Jun Chang and Hyukjin Lee",

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T1 - Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy

AU - Lee, Kyuri

AU - Kim, Soo Young

AU - Seo, Yunmi

AU - Kim, Myung Hee

AU - Chang, Jun

AU - Lee, Hyukjin

PY - 2020/2/21

Y1 - 2020/2/21

N2 - For mRNA mediated cancer immunotherapy, Pam3 was incorporated as an adjuvant within lipid nanoparticles (LNPs) with OVA mRNA. The developed Pam3 incorporated LNPs showed successful expression of tumor antigens with enhanced immune stimulation. We demonstrated that the synergies of Pam3 LNPs could greatly improve the efficacy of tumor prevention by mRNA vaccines.

AB - For mRNA mediated cancer immunotherapy, Pam3 was incorporated as an adjuvant within lipid nanoparticles (LNPs) with OVA mRNA. The developed Pam3 incorporated LNPs showed successful expression of tumor antigens with enhanced immune stimulation. We demonstrated that the synergies of Pam3 LNPs could greatly improve the efficacy of tumor prevention by mRNA vaccines.

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U2 - 10.1039/c9bm01564g

DO - 10.1039/c9bm01564g

M3 - Article

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AN - SCOPUS:85080847366

SN - 2047-4830

VL - 8

SP - 1101

EP - 1105

JO - Biomaterials Science

JF - Biomaterials Science

IS - 4

ER -

Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy

Abstract

Bibliographical note

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