TY - JOUR
T1 - Adiposity parameters and cognitive function in the elderly
T2 - Application of "Jolly Fat" hypothesis to cognition
AU - Han, Changsu
AU - Jo, Sangmee Ahn
AU - Seo, Ji A.
AU - Kim, Byoung Gwon
AU - Kim, Nan Hee
AU - Jo, Inho
AU - Park, Moon Ho
AU - Park, Kun Woo
N1 - Funding Information:
The authors thank the subjects for their willingness to participate in this study. This study was mainly supported by Korea National Institute of Health Intramural Research Grant (091-4800-4845-300-210-13) and the grant (A050079) of the Korea Health 21 R&D Project from the Ministry of Health and Welfare and partly by Korea University Grant (to Dr. Park MH).
PY - 2009/9
Y1 - 2009/9
N2 - Obesity has a strong association with cardiovascular and metabolic diseases, which have also been linked with dementia. While recent studies have reported an association between mid-life obesity and dementia, the role that later-life obesity may have is less clear. A total of 721 community-dwelling elderly (60-85 years old) were selected. Obesity parameters, like body mass index (BMI), waist-hip ratio (WHR), waist circumference (WC), and percent body fat (PBF), as well as cognitive functions were measured over a period of approximately 2 years, and then the relationships between these variables were assessed. The change in cognitive function in the elderly was associated with the baseline assessment of BMI (linearly, β = 0.092), WC (quadratic, β = 1.333), and PBF (linearly, β = 0.097). Using multiple regression analyses, the differences exist in the change of cognitive function over time according to the sex. For men, increased obesity over time when obese in the baseline assessment (BMI, WHR, WC) were associated with a positive change in cognitive function. For women, a decreased obesity over time when obese in the baseline assessment (WHR) and an increased obesity over time when they had a normal adiposity in the baseline assessment (WC) were both associated with cognitive decline. The relationship between obesity and cognitive decline in the elderly is complex and some differences exist between the sexes. The application of the "Jolly Fat" hypothesis to cognitive function can only be applied to elderly men and not to elderly women.
AB - Obesity has a strong association with cardiovascular and metabolic diseases, which have also been linked with dementia. While recent studies have reported an association between mid-life obesity and dementia, the role that later-life obesity may have is less clear. A total of 721 community-dwelling elderly (60-85 years old) were selected. Obesity parameters, like body mass index (BMI), waist-hip ratio (WHR), waist circumference (WC), and percent body fat (PBF), as well as cognitive functions were measured over a period of approximately 2 years, and then the relationships between these variables were assessed. The change in cognitive function in the elderly was associated with the baseline assessment of BMI (linearly, β = 0.092), WC (quadratic, β = 1.333), and PBF (linearly, β = 0.097). Using multiple regression analyses, the differences exist in the change of cognitive function over time according to the sex. For men, increased obesity over time when obese in the baseline assessment (BMI, WHR, WC) were associated with a positive change in cognitive function. For women, a decreased obesity over time when obese in the baseline assessment (WHR) and an increased obesity over time when they had a normal adiposity in the baseline assessment (WC) were both associated with cognitive decline. The relationship between obesity and cognitive decline in the elderly is complex and some differences exist between the sexes. The application of the "Jolly Fat" hypothesis to cognitive function can only be applied to elderly men and not to elderly women.
KW - Adiposity in elderly
KW - Cognitive function
KW - Obesity in elderly
KW - The "Jolly Fat" hypothesis
UR - http://www.scopus.com/inward/record.url?scp=67649716971&partnerID=8YFLogxK
U2 - 10.1016/j.archger.2008.11.005
DO - 10.1016/j.archger.2008.11.005
M3 - Article
C2 - 19108905
AN - SCOPUS:67649716971
SN - 0167-4943
VL - 49
SP - e133-e138
JO - Archives of Gerontology and Geriatrics
JF - Archives of Gerontology and Geriatrics
IS - 2
ER -
