Adenosine derivatives from Cordyceps exert antitumor effects against ovarian cancer cells through ENT1-mediated transport, induction of AMPK signaling, and consequent autophagic cell death

So Young Yoon, Anders M. Lindroth, Soyoung Kwon, Soo Jung Park, Yoon Jung Park

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Cordyceps militaris is rich in adenosine derivatives, including 3′-deoxyadenosine, also known as cordycepin. It has been reported for antitumor effects, but its underlying molecular mechanism has yet to be elucidated. We investigated how adenosine derivatives exerted antitumor effects against ovarian cancer using human ovarian cancer cells and a xenograft mouse model. Treatment with adenosine derivatives effectively resulted in cell death of ovarian cancer cells through AMPK activation and subsequently mTOR-mediated autophagic induction. Intriguingly, the effect required membrane transport of adenosine derivatives via ENT1, rather than ADORA-mediated cellular signaling. Our data suggest that adenosine derivatives may be an effective therapeutic intervention in ovarian cancer through induction of ENT1-AMPK-mTOR-mediated autophagic cell death.

Original languageEnglish
Article number113491
JournalBiomedicine and Pharmacotherapy
Volume153
DOIs
StatePublished - Sep 2022

Keywords

  • Adenosine derivatives
  • AMPK
  • Autophagy
  • Cordyceps militaris
  • ENT1
  • Ovarian cancer

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