Additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with a peroxyl radical: Mechanistic insight into lipoxygenase

Hironori Kitaguchi; Kei Ohkubo; Seiji Ogo; Shunichi Fukuzumi

doi:10.1039/b515004c

Additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with a peroxyl radical: Mechanistic insight into lipoxygenase

Hironori Kitaguchi, Kei Ohkubo, Seiji Ogo, Shunichi Fukuzumi

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A simple additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with cumylperoxyl radical, which is expressed by the additive contributions of the reactivity of active hydrogens from the 1,4-pentadiene subunit and those of the allylic subunit; the kinetic isotope effect on the hydrogen transfer reactions (KIE = 6.1) is significantly smaller than that observed for lipoxygenase (KIE = 81).

Original language	English
Pages (from-to)	979-981
Number of pages	3
Journal	Chemical Communications
Issue number	9
DOIs	https://doi.org/10.1039/b515004c
State	Published - 2006

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title = "Additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with a peroxyl radical: Mechanistic insight into lipoxygenase",

abstract = "A simple additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with cumylperoxyl radical, which is expressed by the additive contributions of the reactivity of active hydrogens from the 1,4-pentadiene subunit and those of the allylic subunit; the kinetic isotope effect on the hydrogen transfer reactions (KIE = 6.1) is significantly smaller than that observed for lipoxygenase (KIE = 81).",

author = "Hironori Kitaguchi and Kei Ohkubo and Seiji Ogo and Shunichi Fukuzumi",

year = "2006",

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AU - Ogo, Seiji

AU - Fukuzumi, Shunichi

PY - 2006

Y1 - 2006

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Additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with a peroxyl radical: Mechanistic insight into lipoxygenase

Abstract

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