Adding value to plant oils and fatty acids: Biological transformation of fatty acids into ω-hydroxycarboxylic, α,ω-dicarboxylic, and ω-aminocarboxylic acids

Joo Hyun Seo, Sun Mee Lee, Jinwon Lee, Jin Byung Park

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations

Abstract

Not only short chain ω-hydroxycarboxylic acids, α,ω-dicarboxylic acids, and ω-aminocarboxylic acids but also medium to long chain carboxylic acids are widely used as building blocks and intermediates in the chemical, pharmaceutical, and food industries. Thereby, recent achievements in biological production of medium to long chain carboxylic acids are addressed here. ω-Hydroxycarboxylic and α,ω-dicarboxylic acids were synthesized via terminal C. H bond oxygenation of fatty acids and/or internal oxidative cleavage of the fatty acid carbon skeletons. ω-Aminocarboxylic acids were enzymatically produced from ω-hydroxycarboxylic acids via ω-oxocarboxylic acids. Productivities and product yields of some of the products are getting close to the industrial requirements for large scale production.

Original languageEnglish
Pages (from-to)158-166
Number of pages9
JournalJournal of Biotechnology
Volume216
DOIs
StatePublished - 20 Dec 2015

Keywords

  • Biotransformation
  • Fatty acids
  • α,ω-Dicarboxylic acids
  • ω-Aminocarboxylic acids
  • ω-Hydroxycarboxylic acids

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