TY - JOUR
T1 - Adding value to plant oils and fatty acids
T2 - Biological transformation of fatty acids into ω-hydroxycarboxylic, α,ω-dicarboxylic, and ω-aminocarboxylic acids
AU - Seo, Joo Hyun
AU - Lee, Sun Mee
AU - Lee, Jinwon
AU - Park, Jin Byung
N1 - Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/12/20
Y1 - 2015/12/20
N2 - Not only short chain ω-hydroxycarboxylic acids, α,ω-dicarboxylic acids, and ω-aminocarboxylic acids but also medium to long chain carboxylic acids are widely used as building blocks and intermediates in the chemical, pharmaceutical, and food industries. Thereby, recent achievements in biological production of medium to long chain carboxylic acids are addressed here. ω-Hydroxycarboxylic and α,ω-dicarboxylic acids were synthesized via terminal C. H bond oxygenation of fatty acids and/or internal oxidative cleavage of the fatty acid carbon skeletons. ω-Aminocarboxylic acids were enzymatically produced from ω-hydroxycarboxylic acids via ω-oxocarboxylic acids. Productivities and product yields of some of the products are getting close to the industrial requirements for large scale production.
AB - Not only short chain ω-hydroxycarboxylic acids, α,ω-dicarboxylic acids, and ω-aminocarboxylic acids but also medium to long chain carboxylic acids are widely used as building blocks and intermediates in the chemical, pharmaceutical, and food industries. Thereby, recent achievements in biological production of medium to long chain carboxylic acids are addressed here. ω-Hydroxycarboxylic and α,ω-dicarboxylic acids were synthesized via terminal C. H bond oxygenation of fatty acids and/or internal oxidative cleavage of the fatty acid carbon skeletons. ω-Aminocarboxylic acids were enzymatically produced from ω-hydroxycarboxylic acids via ω-oxocarboxylic acids. Productivities and product yields of some of the products are getting close to the industrial requirements for large scale production.
KW - Biotransformation
KW - Fatty acids
KW - α,ω-Dicarboxylic acids
KW - ω-Aminocarboxylic acids
KW - ω-Hydroxycarboxylic acids
UR - http://www.scopus.com/inward/record.url?scp=84951970723&partnerID=8YFLogxK
U2 - 10.1016/j.jbiotec.2015.10.024
DO - 10.1016/j.jbiotec.2015.10.024
M3 - Review article
C2 - 26546054
AN - SCOPUS:84951970723
SN - 0168-1656
VL - 216
SP - 158
EP - 166
JO - Journal of Biotechnology
JF - Journal of Biotechnology
ER -