Acute intake of mulberry leaf aqueous extract affects postprandial glucose response after maltose loading: Randomized double-blind placebo-controlled pilot study

Hye In Chung; Joohee Kim; Ji Yeon Kim; Oran Kwon

doi:10.1016/j.jff.2013.04.015

Acute intake of mulberry leaf aqueous extract affects postprandial glucose response after maltose loading: Randomized double-blind placebo-controlled pilot study

Hye In Chung, Joohee Kim, Ji Yeon Kim, Oran Kwon

Department of Nutritional Science & Food Management

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Mulberry leaf extract was investigated as a potent alpha-glucosidase inhibitor, especially for individuals with prediabetes. We evaluated the effect of the ingestion of mulberry leaf aqueous extract (MLAE) on postprandial glucose responses in healthy subjects. We carried out a randomized, double-blind, placebo-controlled trial to determine the intake amount of MLAE (1.25, 2.5, or 5. g) and time necessary to impact postprandial blood glucose levels after 75. g of maltose loading in 50 healthy subjects. Ingestion of MLAE led to a decrease in postchallenge acute glucose levels following intake of 2.5 or 5. g of MLAE at 30 and 60. min (P = 0.0137 and 0.0423, respectively). There was no significant difference between pre- and simultaneous administration of MLAE. The ingestion of MLAE resulted in improved postprandial glycemic control in healthy subjects.

Original language	English
Pages (from-to)	1502-1506
Number of pages	5
Journal	Journal of Functional Foods
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/j.jff.2013.04.015
State	Published - Jul 2013

Bibliographical note

Funding Information:
The authors are grateful to the participants of this study. We also thank to Dr. Kyung-Hee Chung and Dr. Ji-Hyang Wee for the preparation of MLAE. This work was supported by the Ministry of Knowledge & Economy (RITD Program, Project No. 2008-2769-2-3) and by the Ministry of Education, Science, and Technology (NRF Project No. 2012M3A9C4048761).

Keywords

1-Deoxynojirimycin
Mulberry leaf aqueous extract
Postprandial glycemic control

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title = "Acute intake of mulberry leaf aqueous extract affects postprandial glucose response after maltose loading: Randomized double-blind placebo-controlled pilot study",

abstract = "Mulberry leaf extract was investigated as a potent alpha-glucosidase inhibitor, especially for individuals with prediabetes. We evaluated the effect of the ingestion of mulberry leaf aqueous extract (MLAE) on postprandial glucose responses in healthy subjects. We carried out a randomized, double-blind, placebo-controlled trial to determine the intake amount of MLAE (1.25, 2.5, or 5. g) and time necessary to impact postprandial blood glucose levels after 75. g of maltose loading in 50 healthy subjects. Ingestion of MLAE led to a decrease in postchallenge acute glucose levels following intake of 2.5 or 5. g of MLAE at 30 and 60. min (P = 0.0137 and 0.0423, respectively). There was no significant difference between pre- and simultaneous administration of MLAE. The ingestion of MLAE resulted in improved postprandial glycemic control in healthy subjects.",

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author = "Chung, {Hye In} and Joohee Kim and Kim, {Ji Yeon} and Oran Kwon",

note = "Funding Information: The authors are grateful to the participants of this study. We also thank to Dr. Kyung-Hee Chung and Dr. Ji-Hyang Wee for the preparation of MLAE. This work was supported by the Ministry of Knowledge & Economy (RITD Program, Project No. 2008-2769-2-3) and by the Ministry of Education, Science, and Technology (NRF Project No. 2012M3A9C4048761).",

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AU - Kwon, Oran

N1 - Funding Information: The authors are grateful to the participants of this study. We also thank to Dr. Kyung-Hee Chung and Dr. Ji-Hyang Wee for the preparation of MLAE. This work was supported by the Ministry of Knowledge & Economy (RITD Program, Project No. 2008-2769-2-3) and by the Ministry of Education, Science, and Technology (NRF Project No. 2012M3A9C4048761).

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Acute intake of mulberry leaf aqueous extract affects postprandial glucose response after maltose loading: Randomized double-blind placebo-controlled pilot study

Abstract

Bibliographical note

Keywords

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