Acute intake of mulberry leaf aqueous extract affects postprandial glucose response after maltose loading: Randomized double-blind placebo-controlled pilot study

Hye In Chung, Joohee Kim, Ji Yeon Kim, Oran Kwon

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Mulberry leaf extract was investigated as a potent alpha-glucosidase inhibitor, especially for individuals with prediabetes. We evaluated the effect of the ingestion of mulberry leaf aqueous extract (MLAE) on postprandial glucose responses in healthy subjects. We carried out a randomized, double-blind, placebo-controlled trial to determine the intake amount of MLAE (1.25, 2.5, or 5. g) and time necessary to impact postprandial blood glucose levels after 75. g of maltose loading in 50 healthy subjects. Ingestion of MLAE led to a decrease in postchallenge acute glucose levels following intake of 2.5 or 5. g of MLAE at 30 and 60. min (P = 0.0137 and 0.0423, respectively). There was no significant difference between pre- and simultaneous administration of MLAE. The ingestion of MLAE resulted in improved postprandial glycemic control in healthy subjects.

Original languageEnglish
Pages (from-to)1502-1506
Number of pages5
JournalJournal of Functional Foods
Volume5
Issue number3
DOIs
StatePublished - Jul 2013

Keywords

  • 1-Deoxynojirimycin
  • Mulberry leaf aqueous extract
  • Postprandial glycemic control

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