Abstract
Mulberry leaf extract was investigated as a potent alpha-glucosidase inhibitor, especially for individuals with prediabetes. We evaluated the effect of the ingestion of mulberry leaf aqueous extract (MLAE) on postprandial glucose responses in healthy subjects. We carried out a randomized, double-blind, placebo-controlled trial to determine the intake amount of MLAE (1.25, 2.5, or 5. g) and time necessary to impact postprandial blood glucose levels after 75. g of maltose loading in 50 healthy subjects. Ingestion of MLAE led to a decrease in postchallenge acute glucose levels following intake of 2.5 or 5. g of MLAE at 30 and 60. min (P = 0.0137 and 0.0423, respectively). There was no significant difference between pre- and simultaneous administration of MLAE. The ingestion of MLAE resulted in improved postprandial glycemic control in healthy subjects.
Original language | English |
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Pages (from-to) | 1502-1506 |
Number of pages | 5 |
Journal | Journal of Functional Foods |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - Jul 2013 |
Bibliographical note
Funding Information:The authors are grateful to the participants of this study. We also thank to Dr. Kyung-Hee Chung and Dr. Ji-Hyang Wee for the preparation of MLAE. This work was supported by the Ministry of Knowledge & Economy (RITD Program, Project No. 2008-2769-2-3) and by the Ministry of Education, Science, and Technology (NRF Project No. 2012M3A9C4048761).
Keywords
- 1-Deoxynojirimycin
- Mulberry leaf aqueous extract
- Postprandial glycemic control