TY - JOUR
T1 - Acute intake of mulberry leaf aqueous extract affects postprandial glucose response after maltose loading
T2 - Randomized double-blind placebo-controlled pilot study
AU - Chung, Hye In
AU - Kim, Joohee
AU - Kim, Ji Yeon
AU - Kwon, Oran
N1 - Funding Information:
The authors are grateful to the participants of this study. We also thank to Dr. Kyung-Hee Chung and Dr. Ji-Hyang Wee for the preparation of MLAE. This work was supported by the Ministry of Knowledge & Economy (RITD Program, Project No. 2008-2769-2-3) and by the Ministry of Education, Science, and Technology (NRF Project No. 2012M3A9C4048761).
PY - 2013/7
Y1 - 2013/7
N2 - Mulberry leaf extract was investigated as a potent alpha-glucosidase inhibitor, especially for individuals with prediabetes. We evaluated the effect of the ingestion of mulberry leaf aqueous extract (MLAE) on postprandial glucose responses in healthy subjects. We carried out a randomized, double-blind, placebo-controlled trial to determine the intake amount of MLAE (1.25, 2.5, or 5. g) and time necessary to impact postprandial blood glucose levels after 75. g of maltose loading in 50 healthy subjects. Ingestion of MLAE led to a decrease in postchallenge acute glucose levels following intake of 2.5 or 5. g of MLAE at 30 and 60. min (P = 0.0137 and 0.0423, respectively). There was no significant difference between pre- and simultaneous administration of MLAE. The ingestion of MLAE resulted in improved postprandial glycemic control in healthy subjects.
AB - Mulberry leaf extract was investigated as a potent alpha-glucosidase inhibitor, especially for individuals with prediabetes. We evaluated the effect of the ingestion of mulberry leaf aqueous extract (MLAE) on postprandial glucose responses in healthy subjects. We carried out a randomized, double-blind, placebo-controlled trial to determine the intake amount of MLAE (1.25, 2.5, or 5. g) and time necessary to impact postprandial blood glucose levels after 75. g of maltose loading in 50 healthy subjects. Ingestion of MLAE led to a decrease in postchallenge acute glucose levels following intake of 2.5 or 5. g of MLAE at 30 and 60. min (P = 0.0137 and 0.0423, respectively). There was no significant difference between pre- and simultaneous administration of MLAE. The ingestion of MLAE resulted in improved postprandial glycemic control in healthy subjects.
KW - 1-Deoxynojirimycin
KW - Mulberry leaf aqueous extract
KW - Postprandial glycemic control
UR - http://www.scopus.com/inward/record.url?scp=84880511971&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2013.04.015
DO - 10.1016/j.jff.2013.04.015
M3 - Article
AN - SCOPUS:84880511971
SN - 1756-4646
VL - 5
SP - 1502
EP - 1506
JO - Journal of Functional Foods
JF - Journal of Functional Foods
IS - 3
ER -