Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy

Hee Jung Yi; Kyung Sook Hong; Nara Moon; Soon Sup Chung; Ryung Ah Lee; Kwang Ho Kim

doi:10.4174/astr.2016.90.3.179

Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy

Hee Jung Yi, Kyung Sook Hong, Nara Moon, Soon Sup Chung, Ryung Ah Lee, Kwang Ho Kim

Department of Surgery

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy.

Original language	English
Pages (from-to)	179-182
Number of pages	4
Journal	Annals of Surgical Treatment and Research
Volume	9
Issue number	3
DOIs	https://doi.org/10.4174/astr.2016.90.3.179
State	Published - Mar 2016

Bibliographical note

Publisher Copyright:
Copyright © 2016, the Korean Surgical Society.

Keywords

5-Fluorouracil
Colorectal neoplasma
Hyperammonemia
Metabolic brain diseases

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10.4174/astr.2016.90.3.179

Cite this

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title = "Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy",

abstract = "5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy.",

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author = "Yi, \{Hee Jung\} and Hong, \{Kyung Sook\} and Nara Moon and Chung, \{Soon Sup\} and Lee, \{Ryung Ah\} and Kim, \{Kwang Ho\}",

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year = "2016",

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doi = "10.4174/astr.2016.90.3.179",

language = "English",

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T1 - Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy

AU - Yi, Hee Jung

AU - Hong, Kyung Sook

AU - Moon, Nara

AU - Chung, Soon Sup

AU - Lee, Ryung Ah

AU - Kim, Kwang Ho

PY - 2016/3

Y1 - 2016/3

N2 - 5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy.

AB - 5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy.

KW - 5-Fluorouracil

KW - Colorectal neoplasma

KW - Hyperammonemia

KW - Metabolic brain diseases

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Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy

Abstract

Bibliographical note

Keywords

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