Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy

Hee Jung Yi, Kyung Sook Hong, Nara Moon, Soon Sup Chung, Ryung Ah Lee, Kwang Ho Kim

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22 Scopus citations


5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalAnnals of Surgical Treatment and Research
Issue number3
StatePublished - Mar 2016

Bibliographical note

Publisher Copyright:
Copyright © 2016, the Korean Surgical Society.


  • 5-Fluorouracil
  • Colorectal neoplasma
  • Hyperammonemia
  • Metabolic brain diseases


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