Abstract
5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy.
Original language | English |
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Pages (from-to) | 179-182 |
Number of pages | 4 |
Journal | Annals of Surgical Treatment and Research |
Volume | 9 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2016 |
Bibliographical note
Publisher Copyright:Copyright © 2016, the Korean Surgical Society.
Keywords
- 5-Fluorouracil
- Colorectal neoplasma
- Hyperammonemia
- Metabolic brain diseases