TY - JOUR
T1 - Activated supramolecular nano-agents
T2 - From diagnosis to imaging-guided tumor treatment
AU - Han, Jingjing
AU - Li, Haidong
AU - Yoon, Juyoung
N1 - Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education ( 2021R1A6A1A10039823 ).
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/4
Y1 - 2022/4
N2 - Supramolecular well-ordered nanomaterials have been successfully amplifying the efficiency of phototherapy in early diagnosis and timely remedies through noncovalent interactions that precisely modulate their physicochemical properties. This review emphasizes the problem-solving approach of phototherapy and how to overcome its inherent imperfections by fabricating an innovative supramolecular photosensitizer, applying hypoxic conditions, and improving depth penetration. An enhanced understanding of the basics of the programmed activated mechanism of supramolecular assembly could lead to simpler and more environmentally friendly strategies for in vivo targeting of tumor sites, fewer side effects on normal tissues, safer and more effective profiles of the designed nanomaterials, and, ultimately, improved clinical results.
AB - Supramolecular well-ordered nanomaterials have been successfully amplifying the efficiency of phototherapy in early diagnosis and timely remedies through noncovalent interactions that precisely modulate their physicochemical properties. This review emphasizes the problem-solving approach of phototherapy and how to overcome its inherent imperfections by fabricating an innovative supramolecular photosensitizer, applying hypoxic conditions, and improving depth penetration. An enhanced understanding of the basics of the programmed activated mechanism of supramolecular assembly could lead to simpler and more environmentally friendly strategies for in vivo targeting of tumor sites, fewer side effects on normal tissues, safer and more effective profiles of the designed nanomaterials, and, ultimately, improved clinical results.
KW - Activatable agents
KW - Diagnosis
KW - Photodynamic Therapy
KW - Supramolecular assembly
KW - Visualization
UR - http://www.scopus.com/inward/record.url?scp=85123030186&partnerID=8YFLogxK
U2 - 10.1016/j.nantod.2022.101392
DO - 10.1016/j.nantod.2022.101392
M3 - Review article
AN - SCOPUS:85123030186
SN - 1748-0132
VL - 43
JO - Nano Today
JF - Nano Today
M1 - 101392
ER -