Activated supramolecular nano-agents: From diagnosis to imaging-guided tumor treatment

Jingjing Han; Haidong Li; Juyoung Yoon

doi:10.1016/j.nantod.2022.101392

Activated supramolecular nano-agents: From diagnosis to imaging-guided tumor treatment

Jingjing Han, Haidong Li, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Supramolecular well-ordered nanomaterials have been successfully amplifying the efficiency of phototherapy in early diagnosis and timely remedies through noncovalent interactions that precisely modulate their physicochemical properties. This review emphasizes the problem-solving approach of phototherapy and how to overcome its inherent imperfections by fabricating an innovative supramolecular photosensitizer, applying hypoxic conditions, and improving depth penetration. An enhanced understanding of the basics of the programmed activated mechanism of supramolecular assembly could lead to simpler and more environmentally friendly strategies for in vivo targeting of tumor sites, fewer side effects on normal tissues, safer and more effective profiles of the designed nanomaterials, and, ultimately, improved clinical results.

Original language	English
Article number	101392
Journal	Nano Today
Volume	43
DOIs	https://doi.org/10.1016/j.nantod.2022.101392
State	Published - Apr 2022

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education ( 2021R1A6A1A10039823 ).

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

Activatable agents
Diagnosis
Photodynamic Therapy
Supramolecular assembly
Visualization

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10.1016/j.nantod.2022.101392

Cite this

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title = "Activated supramolecular nano-agents: From diagnosis to imaging-guided tumor treatment",

abstract = "Supramolecular well-ordered nanomaterials have been successfully amplifying the efficiency of phototherapy in early diagnosis and timely remedies through noncovalent interactions that precisely modulate their physicochemical properties. This review emphasizes the problem-solving approach of phototherapy and how to overcome its inherent imperfections by fabricating an innovative supramolecular photosensitizer, applying hypoxic conditions, and improving depth penetration. An enhanced understanding of the basics of the programmed activated mechanism of supramolecular assembly could lead to simpler and more environmentally friendly strategies for in vivo targeting of tumor sites, fewer side effects on normal tissues, safer and more effective profiles of the designed nanomaterials, and, ultimately, improved clinical results.",

keywords = "Activatable agents, Diagnosis, Photodynamic Therapy, Supramolecular assembly, Visualization",

author = "Jingjing Han and Haidong Li and Juyoung Yoon",

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doi = "10.1016/j.nantod.2022.101392",

language = "English",

volume = "43",

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T2 - From diagnosis to imaging-guided tumor treatment

AU - Han, Jingjing

AU - Li, Haidong

AU - Yoon, Juyoung

N1 - Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education ( 2021R1A6A1A10039823 ). Publisher Copyright: © 2022 Elsevier Ltd

PY - 2022/4

Y1 - 2022/4

N2 - Supramolecular well-ordered nanomaterials have been successfully amplifying the efficiency of phototherapy in early diagnosis and timely remedies through noncovalent interactions that precisely modulate their physicochemical properties. This review emphasizes the problem-solving approach of phototherapy and how to overcome its inherent imperfections by fabricating an innovative supramolecular photosensitizer, applying hypoxic conditions, and improving depth penetration. An enhanced understanding of the basics of the programmed activated mechanism of supramolecular assembly could lead to simpler and more environmentally friendly strategies for in vivo targeting of tumor sites, fewer side effects on normal tissues, safer and more effective profiles of the designed nanomaterials, and, ultimately, improved clinical results.

AB - Supramolecular well-ordered nanomaterials have been successfully amplifying the efficiency of phototherapy in early diagnosis and timely remedies through noncovalent interactions that precisely modulate their physicochemical properties. This review emphasizes the problem-solving approach of phototherapy and how to overcome its inherent imperfections by fabricating an innovative supramolecular photosensitizer, applying hypoxic conditions, and improving depth penetration. An enhanced understanding of the basics of the programmed activated mechanism of supramolecular assembly could lead to simpler and more environmentally friendly strategies for in vivo targeting of tumor sites, fewer side effects on normal tissues, safer and more effective profiles of the designed nanomaterials, and, ultimately, improved clinical results.

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KW - Diagnosis

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KW - Supramolecular assembly

KW - Visualization

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DO - 10.1016/j.nantod.2022.101392

M3 - Review article

AN - SCOPUS:85123030186

SN - 1748-0132

VL - 43

JO - Nano Today

JF - Nano Today

M1 - 101392

ER -

Activated supramolecular nano-agents: From diagnosis to imaging-guided tumor treatment

Abstract

Bibliographical note

Keywords

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