Supramolecular well-ordered nanomaterials have been successfully amplifying the efficiency of phototherapy in early diagnosis and timely remedies through noncovalent interactions that precisely modulate their physicochemical properties. This review emphasizes the problem-solving approach of phototherapy and how to overcome its inherent imperfections by fabricating an innovative supramolecular photosensitizer, applying hypoxic conditions, and improving depth penetration. An enhanced understanding of the basics of the programmed activated mechanism of supramolecular assembly could lead to simpler and more environmentally friendly strategies for in vivo targeting of tumor sites, fewer side effects on normal tissues, safer and more effective profiles of the designed nanomaterials, and, ultimately, improved clinical results.
Bibliographical noteFunding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education ( 2021R1A6A1A10039823 ).
© 2022 Elsevier Ltd
- Activatable agents
- Photodynamic Therapy
- Supramolecular assembly