Activatable supramolecular photosensitizers: Advanced design strategies

Mengyao Yang, Xingshu Li, Juyoung Yoon

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Activatable photosensitizers (aPSs) are a new, switchable smart photosensitizer (PS) that can enhance photodynamic therapy (PDT) specificity and efficiency. aPSs are inert in healthy tissues, but can be switched on by neoplastic-associated endogenous stimuli such as pH, enzymes, and glutathione (GSH) and reduce damage to normal cells. This review summarizes aPS-based design strategies based on energy or electron transfer and self-quenching. We supplement the advanced design strategies with newly-developed molecular aPSs and focus on introducing nano-engineering supramolecular aPS construction.

Original languageEnglish
Pages (from-to)1683-1693
Number of pages11
JournalMaterials Chemistry Frontiers
Issue number4
StatePublished - 21 Feb 2021


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