Activatable supramolecular photosensitizers: Advanced design strategies

Mengyao Yang; Xingshu Li; Juyoung Yoon

doi:10.1039/d0qm00827c

Activatable supramolecular photosensitizers: Advanced design strategies

Mengyao Yang, Xingshu Li, Juyoung Yoon

Chemistry & Nanoscience

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Activatable photosensitizers (aPSs) are a new, switchable smart photosensitizer (PS) that can enhance photodynamic therapy (PDT) specificity and efficiency. aPSs are inert in healthy tissues, but can be switched on by neoplastic-associated endogenous stimuli such as pH, enzymes, and glutathione (GSH) and reduce damage to normal cells. This review summarizes aPS-based design strategies based on energy or electron transfer and self-quenching. We supplement the advanced design strategies with newly-developed molecular aPSs and focus on introducing nano-engineering supramolecular aPS construction.

Original language	English
Pages (from-to)	1683-1693
Number of pages	11
Journal	Materials Chemistry Frontiers
Volume	5
Issue number	4
DOIs	https://doi.org/10.1039/d0qm00827c
State	Published - 21 Feb 2021

Access to Document

10.1039/d0qm00827c

Cite this

@article{369493d755ca4107aa32fd6eae8a4e72,

title = "Activatable supramolecular photosensitizers: Advanced design strategies",

abstract = "Activatable photosensitizers (aPSs) are a new, switchable smart photosensitizer (PS) that can enhance photodynamic therapy (PDT) specificity and efficiency. aPSs are inert in healthy tissues, but can be switched on by neoplastic-associated endogenous stimuli such as pH, enzymes, and glutathione (GSH) and reduce damage to normal cells. This review summarizes aPS-based design strategies based on energy or electron transfer and self-quenching. We supplement the advanced design strategies with newly-developed molecular aPSs and focus on introducing nano-engineering supramolecular aPS construction.",

author = "Mengyao Yang and Xingshu Li and Juyoung Yoon",

note = "Funding Information: Juyoung Yoon thanks the National Research Foundation of Korea (NRF), which is funded by the Korean government (MSIP) (No. 2012R1A3A2048814). Xingshu Li thanks the National Natural Science Foundation of China (Grant No. 22078066). Mengyao Yang thanks the China Scholarship Council (CSC, No. 201904910820). Publisher Copyright: {\textcopyright} the Partner Organisations.",

year = "2021",

month = feb,

day = "21",

doi = "10.1039/d0qm00827c",

language = "English",

volume = "5",

pages = "1683--1693",

journal = "Materials Chemistry Frontiers",

issn = "2052-1537",

publisher = "Royal Society of Chemistry",

number = "4",

}

TY - JOUR

T1 - Activatable supramolecular photosensitizers

T2 - Advanced design strategies

AU - Yang, Mengyao

AU - Li, Xingshu

AU - Yoon, Juyoung

N1 - Funding Information: Juyoung Yoon thanks the National Research Foundation of Korea (NRF), which is funded by the Korean government (MSIP) (No. 2012R1A3A2048814). Xingshu Li thanks the National Natural Science Foundation of China (Grant No. 22078066). Mengyao Yang thanks the China Scholarship Council (CSC, No. 201904910820). Publisher Copyright: © the Partner Organisations.

PY - 2021/2/21

Y1 - 2021/2/21

N2 - Activatable photosensitizers (aPSs) are a new, switchable smart photosensitizer (PS) that can enhance photodynamic therapy (PDT) specificity and efficiency. aPSs are inert in healthy tissues, but can be switched on by neoplastic-associated endogenous stimuli such as pH, enzymes, and glutathione (GSH) and reduce damage to normal cells. This review summarizes aPS-based design strategies based on energy or electron transfer and self-quenching. We supplement the advanced design strategies with newly-developed molecular aPSs and focus on introducing nano-engineering supramolecular aPS construction.

AB - Activatable photosensitizers (aPSs) are a new, switchable smart photosensitizer (PS) that can enhance photodynamic therapy (PDT) specificity and efficiency. aPSs are inert in healthy tissues, but can be switched on by neoplastic-associated endogenous stimuli such as pH, enzymes, and glutathione (GSH) and reduce damage to normal cells. This review summarizes aPS-based design strategies based on energy or electron transfer and self-quenching. We supplement the advanced design strategies with newly-developed molecular aPSs and focus on introducing nano-engineering supramolecular aPS construction.

UR - http://www.scopus.com/inward/record.url?scp=85101394970&partnerID=8YFLogxK

U2 - 10.1039/d0qm00827c

DO - 10.1039/d0qm00827c

M3 - Review article

AN - SCOPUS:85101394970

SN - 2052-1537

VL - 5

SP - 1683

EP - 1693

JO - Materials Chemistry Frontiers

JF - Materials Chemistry Frontiers

IS - 4

ER -

Activatable supramolecular photosensitizers: Advanced design strategies

Abstract

Access to Document

Fingerprint

Cite this