Activatable Photosensitizers: Agents for Selective Photodynamic Therapy

Xingshu Li, Safacan Kolemen, Juyoung Yoon, Engin U. Akkaya

Research output: Contribution to journalReview articlepeer-review

344 Scopus citations

Abstract

Recent developments in the design of bifunctional and activatable photosensitizers rejuvenate the aging field of photodynamic sensitization and photodynamic therapy. While systematic studies have uncovered new dyes that can serve as potential photosensitizers, the most promising results have come from studies aimed at gaining precise control over the location and rate of cytotoxic singlet oxygen generation. As a consequence, higher selectivities and efficiencies in photodynamic treatment protocols are now within reach. This feature article highlights the variety of approaches that have been pursued to improve photodynamic therapy and to transform simple photosensitizers into smarter theranostic agents.

Original languageEnglish
Article number1604053
JournalAdvanced Functional Materials
Volume27
Issue number5
DOIs
StatePublished - 3 Feb 2017

Keywords

  • imaging
  • photochemistry
  • photodynamic therapy
  • photosensitizers
  • singlet oxygen

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