Activatable NIRF/MRI dual imaging probe using bio-inspired coating of glycol chitosan on superparamagnetic iron oxide nanoparticles

In Jae Chung, Seong Ik Jeon, Eui Joon Cha, Youngro Byun, Ick Chan Kwon, Young Il Kim, Kwangmeyung Kim, Cheol Hee Ahn

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

MRI and NIRF multimodal imaging probe was fabricated and investigated. Glycol chitosan coated SPION was decorated by MMP-2 substrate conjugating BHQ-3 and Cy5.5 dye at each end (BCMG-SPION). NIRF signals were recovered in the presence of MMP-2 at a sub-nanomolar level. BCMG-SPION produced the maximum NIRF intensity at 48 h post injection in vivo. Evaluation of the BCMG-SPION in the tumor tissue by MRI showed that relative contrast enhancement was 34% higher than normal muscles. NIRF images of excised organs showed the highest NIRF signal in tumor and the intensity was at least 8 times higher than other organs.

Original languageEnglish
Pages (from-to)403-409
Number of pages7
JournalJournal of Industrial and Engineering Chemistry
Volume76
DOIs
StatePublished - 25 Aug 2019

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through a National Research Foundation of Korea grant funded by the Korean Government (MEST) ( NRF-2017R1A5A1070259 ), National Research Foundation of Korea grant funded by the Korean Government (MSIT) ( NRF-2019R1A2C2008249 ) and the Global Research Lab (GRL) Program through the National Research Foundation of Korea grant funded by the Ministry of Science, ICT, and Future Planning ( NRF-2015K1A1A2072365 ). The Institute of Engineering Research at Seoul National University provided research facilities for this work.

Publisher Copyright:
© 2019 The Korean Society of Industrial and Engineering Chemistry

Keywords

  • Bio-inspired adhesion
  • In vivo dual imaging
  • Iron oxide
  • MRI
  • Nanoparticles
  • Optical imaging

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