Activatable NIRF/MRI dual imaging probe using bio-inspired coating of glycol chitosan on superparamagnetic iron oxide nanoparticles

In Jae Chung; Seong Ik Jeon; Eui Joon Cha; Youngro Byun; Ick Chan Kwon; Young Il Kim; Kwangmeyung Kim; Cheol Hee Ahn

doi:10.1016/j.jiec.2019.04.006

Activatable NIRF/MRI dual imaging probe using bio-inspired coating of glycol chitosan on superparamagnetic iron oxide nanoparticles

In Jae Chung, Seong Ik Jeon, Eui Joon Cha, Youngro Byun, Ick Chan Kwon, Young Il Kim, Kwangmeyung Kim, Cheol Hee Ahn

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

MRI and NIRF multimodal imaging probe was fabricated and investigated. Glycol chitosan coated SPION was decorated by MMP-2 substrate conjugating BHQ-3 and Cy5.5 dye at each end (BCMG-SPION). NIRF signals were recovered in the presence of MMP-2 at a sub-nanomolar level. BCMG-SPION produced the maximum NIRF intensity at 48 h post injection in vivo. Evaluation of the BCMG-SPION in the tumor tissue by MRI showed that relative contrast enhancement was 34% higher than normal muscles. NIRF images of excised organs showed the highest NIRF signal in tumor and the intensity was at least 8 times higher than other organs.

Original language	English
Pages (from-to)	403-409
Number of pages	7
Journal	Journal of Industrial and Engineering Chemistry
Volume	76
DOIs	https://doi.org/10.1016/j.jiec.2019.04.006
State	Published - 25 Aug 2019

Bibliographical note

Publisher Copyright:
© 2019 The Korean Society of Industrial and Engineering Chemistry

Keywords

Bio-inspired adhesion
In vivo dual imaging
Iron oxide
MRI
Nanoparticles
Optical imaging

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10.1016/j.jiec.2019.04.006

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title = "Activatable NIRF/MRI dual imaging probe using bio-inspired coating of glycol chitosan on superparamagnetic iron oxide nanoparticles",

abstract = "MRI and NIRF multimodal imaging probe was fabricated and investigated. Glycol chitosan coated SPION was decorated by MMP-2 substrate conjugating BHQ-3 and Cy5.5 dye at each end (BCMG-SPION). NIRF signals were recovered in the presence of MMP-2 at a sub-nanomolar level. BCMG-SPION produced the maximum NIRF intensity at 48 h post injection in vivo. Evaluation of the BCMG-SPION in the tumor tissue by MRI showed that relative contrast enhancement was 34% higher than normal muscles. NIRF images of excised organs showed the highest NIRF signal in tumor and the intensity was at least 8 times higher than other organs.",

keywords = "Bio-inspired adhesion, In vivo dual imaging, Iron oxide, MRI, Nanoparticles, Optical imaging",

author = "Chung, {In Jae} and Jeon, {Seong Ik} and Cha, {Eui Joon} and Youngro Byun and Kwon, {Ick Chan} and Kim, {Young Il} and Kwangmeyung Kim and Ahn, {Cheol Hee}",

note = "Publisher Copyright: {\textcopyright} 2019 The Korean Society of Industrial and Engineering Chemistry",

year = "2019",

month = aug,

day = "25",

doi = "10.1016/j.jiec.2019.04.006",

language = "English",

volume = "76",

pages = "403--409",

journal = "Journal of Industrial and Engineering Chemistry",

issn = "1226-086X",

publisher = "Korean Society of Industrial Engineering Chemistry",

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T1 - Activatable NIRF/MRI dual imaging probe using bio-inspired coating of glycol chitosan on superparamagnetic iron oxide nanoparticles

AU - Chung, In Jae

AU - Jeon, Seong Ik

AU - Cha, Eui Joon

AU - Byun, Youngro

AU - Kwon, Ick Chan

AU - Kim, Young Il

AU - Kim, Kwangmeyung

AU - Ahn, Cheol Hee

PY - 2019/8/25

Y1 - 2019/8/25

N2 - MRI and NIRF multimodal imaging probe was fabricated and investigated. Glycol chitosan coated SPION was decorated by MMP-2 substrate conjugating BHQ-3 and Cy5.5 dye at each end (BCMG-SPION). NIRF signals were recovered in the presence of MMP-2 at a sub-nanomolar level. BCMG-SPION produced the maximum NIRF intensity at 48 h post injection in vivo. Evaluation of the BCMG-SPION in the tumor tissue by MRI showed that relative contrast enhancement was 34% higher than normal muscles. NIRF images of excised organs showed the highest NIRF signal in tumor and the intensity was at least 8 times higher than other organs.

AB - MRI and NIRF multimodal imaging probe was fabricated and investigated. Glycol chitosan coated SPION was decorated by MMP-2 substrate conjugating BHQ-3 and Cy5.5 dye at each end (BCMG-SPION). NIRF signals were recovered in the presence of MMP-2 at a sub-nanomolar level. BCMG-SPION produced the maximum NIRF intensity at 48 h post injection in vivo. Evaluation of the BCMG-SPION in the tumor tissue by MRI showed that relative contrast enhancement was 34% higher than normal muscles. NIRF images of excised organs showed the highest NIRF signal in tumor and the intensity was at least 8 times higher than other organs.

KW - Bio-inspired adhesion

KW - In vivo dual imaging

KW - Iron oxide

KW - MRI

KW - Nanoparticles

KW - Optical imaging

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U2 - 10.1016/j.jiec.2019.04.006

DO - 10.1016/j.jiec.2019.04.006

M3 - Article

AN - SCOPUS:85064433062

SN - 1226-086X

VL - 76

SP - 403

EP - 409

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -

Activatable NIRF/MRI dual imaging probe using bio-inspired coating of glycol chitosan on superparamagnetic iron oxide nanoparticles

Abstract

Bibliographical note

Keywords

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