Abstract
MRI and NIRF multimodal imaging probe was fabricated and investigated. Glycol chitosan coated SPION was decorated by MMP-2 substrate conjugating BHQ-3 and Cy5.5 dye at each end (BCMG-SPION). NIRF signals were recovered in the presence of MMP-2 at a sub-nanomolar level. BCMG-SPION produced the maximum NIRF intensity at 48 h post injection in vivo. Evaluation of the BCMG-SPION in the tumor tissue by MRI showed that relative contrast enhancement was 34% higher than normal muscles. NIRF images of excised organs showed the highest NIRF signal in tumor and the intensity was at least 8 times higher than other organs.
Original language | English |
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Pages (from-to) | 403-409 |
Number of pages | 7 |
Journal | Journal of Industrial and Engineering Chemistry |
Volume | 76 |
DOIs | |
State | Published - 25 Aug 2019 |
Bibliographical note
Publisher Copyright:© 2019 The Korean Society of Industrial and Engineering Chemistry
Keywords
- Bio-inspired adhesion
- In vivo dual imaging
- Iron oxide
- MRI
- Nanoparticles
- Optical imaging