@article{ee58366a710d476ab664423cabad3757,
title = "Activatable NIRF/MRI dual imaging probe using bio-inspired coating of glycol chitosan on superparamagnetic iron oxide nanoparticles",
abstract = "MRI and NIRF multimodal imaging probe was fabricated and investigated. Glycol chitosan coated SPION was decorated by MMP-2 substrate conjugating BHQ-3 and Cy5.5 dye at each end (BCMG-SPION). NIRF signals were recovered in the presence of MMP-2 at a sub-nanomolar level. BCMG-SPION produced the maximum NIRF intensity at 48 h post injection in vivo. Evaluation of the BCMG-SPION in the tumor tissue by MRI showed that relative contrast enhancement was 34% higher than normal muscles. NIRF images of excised organs showed the highest NIRF signal in tumor and the intensity was at least 8 times higher than other organs.",
keywords = "Bio-inspired adhesion, In vivo dual imaging, Iron oxide, MRI, Nanoparticles, Optical imaging",
author = "Chung, {In Jae} and Jeon, {Seong Ik} and Cha, {Eui Joon} and Youngro Byun and Kwon, {Ick Chan} and Kim, {Young Il} and Kwangmeyung Kim and Ahn, {Cheol Hee}",
note = "Funding Information: This research was supported by the Basic Science Research Program through a National Research Foundation of Korea grant funded by the Korean Government (MEST) ( NRF-2017R1A5A1070259 ), National Research Foundation of Korea grant funded by the Korean Government (MSIT) ( NRF-2019R1A2C2008249 ) and the Global Research Lab (GRL) Program through the National Research Foundation of Korea grant funded by the Ministry of Science, ICT, and Future Planning ( NRF-2015K1A1A2072365 ). The Institute of Engineering Research at Seoul National University provided research facilities for this work. Publisher Copyright: {\textcopyright} 2019 The Korean Society of Industrial and Engineering Chemistry",
year = "2019",
month = aug,
day = "25",
doi = "10.1016/j.jiec.2019.04.006",
language = "English",
volume = "76",
pages = "403--409",
journal = "Journal of Industrial and Engineering Chemistry",
issn = "1226-086X",
publisher = "Korean Society of Industrial Engineering Chemistry",
}