Activatable Near-Infrared Versatile Fluorescent and Chemiluminescent Dyes Based on the Dicyanomethylene-4H-pyran Scaffold: From Design to Imaging and Theranostics

Haidong Li, Jingyun Wang, Heejeong Kim, Xiaojun Peng, Juyoung Yoon

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations

Abstract

Activatable fluorescent and chemiluminescent dyes with near-infrared emission have indispensable roles in the fields of bioimaging, molecular prodrugs, and phototheranostic agents. As one of the most popular fluorophore scaffolds, the dicyanomethylene-4H-pyran scaffold has been applied to fabricate a large number of versatile activatable optical dyes for analytes detection and diseases diagnosis and treatment by virtue of its high photostability, large Stokes shift, considerable two-photon absorption cross-section, and structural modifiability. This review discusses the molecular design strategies, recognition mechanisms, and both in vitro and in vivo bio-applications (especially for diagnosis and therapy of tumors) of activatable dicyanomethylene-4H-pyran dyes. The final section describes the current shortcomings and future development prospects of this topic.

Original languageEnglish
JournalAngewandte Chemie - International Edition
DOIs
StateAccepted/In press - 2023

Bibliographical note

Publisher Copyright:
© 2023 Wiley-VCH GmbH.

Keywords

  • Activatable Fluorescent Probes
  • Dicyanomethylene-4H-Pyran Dyes
  • Fluorescence Imaging
  • NIR Chemiluminescence
  • Theranostics

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