Activatable imaging probes with amplified fluorescent signals

Seulki Lee, Kyeongsoon Park, Kwangmeyung Kim, Kuiwon Choi, Ick Chan Kwon

Research output: Contribution to journalArticlepeer-review

131 Scopus citations


Current optical imaging probe applications are hampered by poor sensitivity and specificity to the target, but molecular-level fluorescent signal activation strategies can efficiently overcome these limitations. Recent interdisciplinary research that couples the imaging sciences to fluorophore, peptide, polymer, and inorganic-based chemistry has generated novel imaging probes that exhibit high sensitivity and low background noise in both in vitro and in vivo applications. This feature article introduces and discusses the various approaches described by the term "fluorescent signal activation methods" with respect to their unique imaging probe design strategies and applications.

Original languageEnglish
Pages (from-to)4250-4260
Number of pages11
JournalChemical Communications
Issue number36
StatePublished - 2008


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