Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp

Sohee Kim; Prima F. Hillman; Ji Young Lee; Juri Lee; Jihye Lee; Sun Shin Cha; Dong Chan Oh; Sang Jip Nam; William Fenical

doi:10.1038/s41429-022-00562-2

Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp

Sohee Kim
, Prima F. Hillman
, Ji Young Lee
, Juri Lee
, Jihye Lee
, Sun Shin Cha
, Dong Chan Oh
, Sang Jip Nam
, William Fenical

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

HPLC-UV-guided fractionation of crude extract from the marine sediment-derived bacterium Streptomyces sp. CNP-944 has yielded two new pyrazine alkaloids, actinopolymorphols E and F (1 and 2), in addition to the previously reported biosynthetic product, actinopolymorphol G (3), and the known actinopolymorphol D (4). The chemical structures of 1−3 were determined based on the interpretation of the 1D, 2D NMR, and MS spectroscopic data. Compound 2 displayed weak antibacterial activities against Kocuria rhizophila, Bacillus subtilis, and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 16, 64, and 64 μg ml⁻¹, respectively.

Original language	English
Pages (from-to)	619-625
Number of pages	7
Journal	Journal of Antibiotics
Volume	75
Issue number	11
DOIs	https://doi.org/10.1038/s41429-022-00562-2
State	Published - Nov 2022

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea grant funded by the Korean Government (Ministry of Science and ICT; no. 2021R1A4A2001251 to S-JN) and in part by the project titled “Development of Potential Antibiotic Compounds Using Polar Organism Resources” (15250103, KOPRI grant PM21030 to S-SC) funded by the Ministry of Oceans and Fisheries, Korea. Isolation of the bacterium strain Streptomyces sp. CNP-944 was a result of financial support from the US National Cancer Institute (grant CA R37044848 to WF).

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.

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SDG 14 Life Below Water

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title = "Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp",

abstract = "HPLC-UV-guided fractionation of crude extract from the marine sediment-derived bacterium Streptomyces sp. CNP-944 has yielded two new pyrazine alkaloids, actinopolymorphols E and F (1 and 2), in addition to the previously reported biosynthetic product, actinopolymorphol G (3), and the known actinopolymorphol D (4). The chemical structures of 1−3 were determined based on the interpretation of the 1D, 2D NMR, and MS spectroscopic data. Compound 2 displayed weak antibacterial activities against Kocuria rhizophila, Bacillus subtilis, and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 16, 64, and 64 μg ml−1, respectively.",

author = "Sohee Kim and Hillman, \{Prima F.\} and Lee, \{Ji Young\} and Juri Lee and Jihye Lee and Cha, \{Sun Shin\} and Oh, \{Dong Chan\} and Nam, \{Sang Jip\} and William Fenical",

note = "Funding Information: This research was supported by the National Research Foundation of Korea grant funded by the Korean Government (Ministry of Science and ICT; no. 2021R1A4A2001251 to S-JN) and in part by the project titled “Development of Potential Antibiotic Compounds Using Polar Organism Resources” (15250103, KOPRI grant PM21030 to S-SC) funded by the Ministry of Oceans and Fisheries, Korea. Isolation of the bacterium strain Streptomyces sp. CNP-944 was a result of financial support from the US National Cancer Institute (grant CA R37044848 to WF). Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.",

year = "2022",

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doi = "10.1038/s41429-022-00562-2",

language = "English",

volume = "75",

pages = "619--625",

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T1 - Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp

AU - Kim, Sohee

AU - Hillman, Prima F.

AU - Lee, Ji Young

AU - Lee, Juri

AU - Lee, Jihye

AU - Cha, Sun Shin

AU - Oh, Dong Chan

AU - Nam, Sang Jip

AU - Fenical, William

N1 - Funding Information: This research was supported by the National Research Foundation of Korea grant funded by the Korean Government (Ministry of Science and ICT; no. 2021R1A4A2001251 to S-JN) and in part by the project titled “Development of Potential Antibiotic Compounds Using Polar Organism Resources” (15250103, KOPRI grant PM21030 to S-SC) funded by the Ministry of Oceans and Fisheries, Korea. Isolation of the bacterium strain Streptomyces sp. CNP-944 was a result of financial support from the US National Cancer Institute (grant CA R37044848 to WF). Publisher Copyright: © 2022, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.

PY - 2022/11

Y1 - 2022/11

N2 - HPLC-UV-guided fractionation of crude extract from the marine sediment-derived bacterium Streptomyces sp. CNP-944 has yielded two new pyrazine alkaloids, actinopolymorphols E and F (1 and 2), in addition to the previously reported biosynthetic product, actinopolymorphol G (3), and the known actinopolymorphol D (4). The chemical structures of 1−3 were determined based on the interpretation of the 1D, 2D NMR, and MS spectroscopic data. Compound 2 displayed weak antibacterial activities against Kocuria rhizophila, Bacillus subtilis, and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 16, 64, and 64 μg ml−1, respectively.

AB - HPLC-UV-guided fractionation of crude extract from the marine sediment-derived bacterium Streptomyces sp. CNP-944 has yielded two new pyrazine alkaloids, actinopolymorphols E and F (1 and 2), in addition to the previously reported biosynthetic product, actinopolymorphol G (3), and the known actinopolymorphol D (4). The chemical structures of 1−3 were determined based on the interpretation of the 1D, 2D NMR, and MS spectroscopic data. Compound 2 displayed weak antibacterial activities against Kocuria rhizophila, Bacillus subtilis, and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 16, 64, and 64 μg ml−1, respectively.

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EP - 625

JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 11

ER -

Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp

Abstract

Bibliographical note

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