TY - JOUR
T1 - Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp
AU - Kim, Sohee
AU - Hillman, Prima F.
AU - Lee, Ji Young
AU - Lee, Juri
AU - Lee, Jihye
AU - Cha, Sun Shin
AU - Oh, Dong Chan
AU - Nam, Sang Jip
AU - Fenical, William
N1 - Funding Information:
This research was supported by the National Research Foundation of Korea grant funded by the Korean Government (Ministry of Science and ICT; no. 2021R1A4A2001251 to S-JN) and in part by the project titled “Development of Potential Antibiotic Compounds Using Polar Organism Resources” (15250103, KOPRI grant PM21030 to S-SC) funded by the Ministry of Oceans and Fisheries, Korea. Isolation of the bacterium strain Streptomyces sp. CNP-944 was a result of financial support from the US National Cancer Institute (grant CA R37044848 to WF).
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.
PY - 2022/11
Y1 - 2022/11
N2 - HPLC-UV-guided fractionation of crude extract from the marine sediment-derived bacterium Streptomyces sp. CNP-944 has yielded two new pyrazine alkaloids, actinopolymorphols E and F (1 and 2), in addition to the previously reported biosynthetic product, actinopolymorphol G (3), and the known actinopolymorphol D (4). The chemical structures of 1−3 were determined based on the interpretation of the 1D, 2D NMR, and MS spectroscopic data. Compound 2 displayed weak antibacterial activities against Kocuria rhizophila, Bacillus subtilis, and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 16, 64, and 64 μg ml−1, respectively.
AB - HPLC-UV-guided fractionation of crude extract from the marine sediment-derived bacterium Streptomyces sp. CNP-944 has yielded two new pyrazine alkaloids, actinopolymorphols E and F (1 and 2), in addition to the previously reported biosynthetic product, actinopolymorphol G (3), and the known actinopolymorphol D (4). The chemical structures of 1−3 were determined based on the interpretation of the 1D, 2D NMR, and MS spectroscopic data. Compound 2 displayed weak antibacterial activities against Kocuria rhizophila, Bacillus subtilis, and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 16, 64, and 64 μg ml−1, respectively.
UR - http://www.scopus.com/inward/record.url?scp=85138018197&partnerID=8YFLogxK
U2 - 10.1038/s41429-022-00562-2
DO - 10.1038/s41429-022-00562-2
M3 - Article
C2 - 36109669
AN - SCOPUS:85138018197
SN - 0021-8820
VL - 75
SP - 619
EP - 625
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 11
ER -
