Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp

Sohee Kim, Prima F. Hillman, Ji Young Lee, Juri Lee, Jihye Lee, Sun Shin Cha, Dong Chan Oh, Sang Jip Nam, William Fenical

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

HPLC-UV-guided fractionation of crude extract from the marine sediment-derived bacterium Streptomyces sp. CNP-944 has yielded two new pyrazine alkaloids, actinopolymorphols E and F (1 and 2), in addition to the previously reported biosynthetic product, actinopolymorphol G (3), and the known actinopolymorphol D (4). The chemical structures of 1−3 were determined based on the interpretation of the 1D, 2D NMR, and MS spectroscopic data. Compound 2 displayed weak antibacterial activities against Kocuria rhizophila, Bacillus subtilis, and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 16, 64, and 64 μg ml−1, respectively.

Original languageEnglish
Pages (from-to)619-625
Number of pages7
JournalJournal of Antibiotics
Volume75
Issue number11
DOIs
StatePublished - Nov 2022

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea grant funded by the Korean Government (Ministry of Science and ICT; no. 2021R1A4A2001251 to S-JN) and in part by the project titled “Development of Potential Antibiotic Compounds Using Polar Organism Resources” (15250103, KOPRI grant PM21030 to S-SC) funded by the Ministry of Oceans and Fisheries, Korea. Isolation of the bacterium strain Streptomyces sp. CNP-944 was a result of financial support from the US National Cancer Institute (grant CA R37044848 to WF).

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.

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